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Query: INSIG1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
INSIG1 0 -1.588 0.090 -0.390

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
INSIG1 Ubiquitylation K273 -1.588 _QLAMGVPEK(gl)PHSD_
INSIG1 Ubiquitylation K305 -2.056 _SPIVIESSK(gl)PPILR_

Background Information for INSIG1:





Protein-protein Interactions for INSIG1

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDH13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in INSIG1

Domain name Domain Description TC-NER relevance -log10(p-value)
Category members INSIG_fam IPR025929 0


Protein complexes (CORUM database) featuring INSIG1

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring INSIG1

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0045599 negative regulation of fat cell differentiation Database 0.13
Category members GO Category GO:0032937 SREBP-SCAP-Insig complex Database 0.09
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0045717 negative regulation of fatty acid biosynthetic process Database 0.02
Category members GO Category GO:0006641 triglyceride metabolic process Database 0
Category members GO Category GO:0006695 cholesterol biosynthetic process Database 0
Category members GO Category GO:0006991 response to sterol depletion Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0010894 negative regulation of steroid biosynthetic process Database 0
Category members GO Category GO:0016126 sterol biosynthetic process Database 0
Category members GO Category GO:0032933 SREBP signaling pathway Database 0
Category members GO Category GO:0042472 inner ear morphogenesis Database 0
Category members GO Category GO:0042474 middle ear morphogenesis Database 0
Category members GO Category GO:0060363 cranial suture morphogenesis Database 0


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