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Query: HUWE1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HUWE1 3 8.770 -1.250 1.500
HUWE1 3 8.770 -1.250 1.500 -0.684 0.362 -0.152

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HUWE1 Phosphorylation S1368 2.745 2.124 _DLS(ph)MSEEDQM(ox)M(ox)R_
HUWE1 Ubiquitylation K324 1.996 _QLMEIK(gl)AASLR_
HUWE1 Ubiquitylation K516 1.194 _SMLNFLK(gl)K_
HUWE1 Ubiquitylation K517 1.194 _SMLNFLK(gl)K_
HUWE1 Phosphorylation S3757 0.931 0.989 _LGSSGLGS(ph)ASSIQAAVR_
HUWE1 Phosphorylation T2889 1.022 0.924 _AGSST(ph)PGDAPPAVAEVQGR_
HUWE1 Ubiquitylation K1713 0.810 _TLEESKEMDIK(gl)R_
HUWE1 Phosphorylation S2377 0.768 _SGEDES(ph)QEDVLMDEAPSNLSQASTLQANR_
HUWE1 Phosphorylation S3662 0.940 0.734 _AQCETLS(ph)PDGLPEEQPQTTK_
HUWE1 Phosphorylation S3753 1.473 0.728 _LGSS(ph)GLGSASSIQAAVR_
HUWE1 Ubiquitylation K4295 0.703 0.688 _AK(gl)FLQFVTGTSK_
HUWE1 Phosphorylation S2532 0.684 _HADHSSLTLGS(ph)GSSTTR_
HUWE1 Ubiquitylation K3997 0.639 0.630 _VLDFDVK(gl)R_
HUWE1 Phosphorylation S1907 0.685 0.593 _GSGTAS(ph)DDEFENLR_
HUWE1 Ubiquitylation K1107 0.382 0.570 _STASALTK(gl)LLTK_
HUWE1 Ubiquitylation K3345 0.581 0.528 _HVLDTLIQLAK(gl)_
HUWE1 Phosphorylation S2372 0.517 _S(ph)GEDESQEDVLMDEAPSNLSQASTLQANR_
HUWE1 Ubiquitylation K1470 0.459 0.499 _VCDLIMTAIK(gl)R_
HUWE1 Phosphorylation S3752 0.910 0.498 _LGS(ph)SGLGSASSIQAAVR_
HUWE1 Ubiquitylation K2219 -0.368 0.472 _K(gl)GLVNDLAR_
HUWE1 Phosphorylation S2362 0.398 0.411 _DGGS(ph)GNSTIIVSR_
HUWE1 Ubiquitylation K3452 0.345 0.352 _SSLLTEK(gl)LLR_
HUWE1 Phosphorylation S3373 0.040 0.333 _ACS(ph)PCSSQSSSSGICTDFWDLLVK_
HUWE1 Ubiquitylation K4116 0.312 _IVAK(gl)AVYDNR_
HUWE1 Phosphorylation S649 0.305 _RSS(ph)DPLGDTASNLGSAVDELMR_
HUWE1 Phosphorylation S1903 0.533 0.300 _GS(ph)GTASDDEFENLR_
HUWE1 Phosphorylation T1905 0.542 0.300 _GSGT(ph)ASDDEFENLR_
HUWE1 Phosphorylation S1395 0.200 0.293 _AES(ph)PEEVACRK_
HUWE1 Phosphorylation T1722 1.903 0.188 _GNDT(ph)PLALESTNTEK_
HUWE1 Phosphorylation S131 0.155 _IQRPNTTQEGEEMETDMDVADVAMESS(ph)PGSSISMEHR_
HUWE1 Ubiquitylation K1840 0.879 0.090 _HTMEK(gl)VVR_
HUWE1 Phosphorylation S648 0.066 _RS(ph)SDPLGDTASNLGSAVDELMR_
HUWE1 Ubiquitylation K674 -0.756 0.052 _HQPTLK(gl)TDATTAIIK_
HUWE1 Ubiquitylation K701 -0.689 0.009 _YICQK(gl)PSIQK_
HUWE1 Ubiquitylation K1037 -0.044 _SK(gl)ITPAMAAR_
HUWE1 Ubiquitylation K1608 0.575 -0.055 _AQMTK(gl)YLQSNSNNWR_
HUWE1 Ubiquitylation K2172 0.867 -0.078 _ALAMAESTEK(gl)HAR_
HUWE1 Ubiquitylation K2267 -0.095 -0.110 _IVNQPSSLFGSK(gl)SASSK_
HUWE1 Ubiquitylation K1708 -0.283 _TLEESK(gl)EMDIK_
HUWE1 Ubiquitylation K3558 -0.045 -0.283 _SPAK(gl)VSDGGSSSTDFK_
HUWE1 Phosphorylation S3816 -0.580 -0.661 _REESPMDVDQPS(ph)PSAQDTQSIASDGTPQGEK_
HUWE1 Ubiquitylation K1917 -1.189 -0.700 _IK(gl)GPNAVQLVK_
HUWE1 Phosphorylation S2887 -0.764 -0.940 _AGS(ph)STPGDAPPAVAEVQGR_
HUWE1 Phosphorylation S2918 -1.072 -1.081 _SDGSGESAQPPEDSS(ph)PPASSESSSTR_
HUWE1 Ubiquitylation K3954 -2.295 -1.326 _EPSSMHISSSLPPDTQK(gl)FLR_
HUWE1 Phosphorylation S2917 -1.340 _SDGSGESAQPPEDS(ph)SPPASSESSSTR_
HUWE1 Ubiquitylation K3677 -1.251 -1.639 _AQCETLSPDGLPEEQPQTTKLK(gl)_
HUWE1 Phosphorylation S3919 -1.085 -1.773 _ESQLAHIKDEPPPLS(ph)PAPLTPATPSSLDPFFSR_
HUWE1 Phosphorylation S3906 -1.731 -2.374 _ES(ph)QLAHIKDEPPPLSPAPLTPATPSSLDPFFSR_
HUWE1 Ubiquitylation K27 -1.058 _ALIDKLK(gl)_
HUWE1 Ubiquitylation K1111 -2.104 _LLTK(gl)GLSWQPPPYTPTPR_
HUWE1 Ubiquitylation K2703 -0.653 _QLAEEETK(gl)ITDK_
HUWE1 Ubiquitylation K3244 -0.067 _SSESELCIETPK(gl)LTTSEEK_
HUWE1 Ubiquitylation K3621 -0.956 _DTVLK(gl)LLLNGAR_
HUWE1 Ubiquitylation K3716 -0.483 _ELQLPSMSMLTSK(gl)TSTQK_
HUWE1 Ubiquitylation K4014 0.012 _LDEGLRK(gl)EDMAVHVR_

Background Information for HUWE1:


Pubmed-HUWE1 »
Uniprot-HUWE1 »
Biogrid-HUWE1 »
ProteomicsDB-HUWE1 »

Tumorportal-HUWE1 »
COSMIC-HUWE1 »
GenomeRNAi-HUWE1 »
Genecards-HUWE1


Protein-protein Interactions for HUWE1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CEP78 Cat. description Hein, Mann, Cell 2015
Category members IP bait CSNK2A2 Cat. description Hein, Mann, Cell 2015
Category members IP bait EZH2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HUWE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC24C Cat. description Hein, Mann, Cell 2015
Category members IP bait VCPIP1 Cat. description Hein, Mann, Cell 2015


Protein Domains in HUWE1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members UBA/Ts_N IPR000449 0.34
Category members UBA-like IPR009060 0.17
Category members HECT IPR000569 0.04
Category members UBA/transl_elong_EF1B_N_euk IPR015940 0.04
Category members WWE-dom IPR004170 0


Protein complexes (CORUM database) featuring HUWE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 220 ARF-Mule complex Database 0.1


Categories featuring HUWE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0016574 histone ubiquitination Database 0.2
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members GO Category GO:0006513 protein monoubiquitination Database 0


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