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Query: HNRNPU

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HNRNPU 2 3.598 0.060 -0.680 -0.369 0.066 -0.683 -0.285
HNRNPU 2 3.598 0.060 -0.680 -0.343 -0.601 -0.104

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HNRNPU Ubiquitylation K265 1.012 1.954 _GYFEYIEENK(gl)YSR_
HNRNPU Ubiquitylation K331 1.838 _ASYGVSK(gl)GK_
HNRNPU Ubiquitylation K524 1.526 1.808 _HAAENPGK(gl)YNILGTNTIMDK_
HNRNPU Ubiquitylation K674 0.609 1.144 _LLEQYKEESK(gl)K_
HNRNPU Ubiquitylation K333 0.588 1.107 _GK(gl)VCFEMK_
HNRNPU Ubiquitylation K544 0.990 0.998 _K(gl)QMADTGKLNTLLQR_
HNRNPU Ubiquitylation K516 0.760 0.963 _TTWVTK(gl)HAAENPGK_
HNRNPU Phosphorylation S59 -0.339 0.750 _LQAALDDEEAGGRPAMEPGNGS(ph)LDLGGDSAGR_
HNRNPU Ubiquitylation K635 -0.542 0.731 _DLPEHAVLK(gl)MK_
HNRNPU Phosphorylation S3 0.613 0.694 _(ac)SS(ph)SPVNVKK_
HNRNPU Ubiquitylation K565 -0.860 0.512 _APQCLGK(gl)FIEIAAR_
HNRNPU Ubiquitylation K10 -0.601 0.483 _(ac)SSSPVNVKK(gl)_
HNRNPU Phosphorylation S4 0.604 0.436 _SSS(ph)PVNVK_
HNRNPU Ubiquitylation K670 0.028 0.169 _LLEQYK(gl)EESK_
HNRNPU Phosphorylation S271 -0.442 -0.479 _AKS(ph)PQPPVEEEDEHFDDTVVCLDTYNCDLHFK_
HNRNPU Ubiquitylation K186 -0.973 -0.548 _EAAGK(gl)SSGPTSLFAVTVAPPGAR_
HNRNPU Phosphorylation T286 -0.661 _AKSPQPPVEEEDEHFDDT(ph)VVCLDTYNCDLHFK_
HNRNPU Ubiquitylation K17 0.825 _VSELK(gl)EELKK_
HNRNPU Ubiquitylation K21 0.440 _VSELKEELK(gl)K_
HNRNPU Ubiquitylation K22 0.251 _VSELKEELKK(gl)_
HNRNPU Ubiquitylation K28 0.318 _LSDK(gl)GLKAELMER_
HNRNPU Ubiquitylation K31 -0.073 _GLK(gl)AELMER_
HNRNPU Ubiquitylation K464 -2.351 _EK(gl)PYFPIPEEYTFIQNVPLEDR_
HNRNPU Ubiquitylation K543 0.423 _MMVAGFK(gl)K_
HNRNPU Ubiquitylation K551 0.793 _QMADTGK(gl)LNTLLQR_
HNRNPU Ubiquitylation K602 0.540 _K(gl)AVVVCPK_
HNRNPU Ubiquitylation K609 0.190 _AVVVCPK(gl)DEDYKQR_
HNRNPU Ubiquitylation K675 1.046 _LLEQYKEESKK(gl)_

Background Information for HNRNPU:


Pubmed-HNRNPU »
Uniprot-HNRNPU »
Biogrid-HNRNPU »
ProteomicsDB-HNRNPU »

Tumorportal-HNRNPU »
COSMIC-HNRNPU »
GenomeRNAi-HNRNPU »
Genecards-HNRNPU


Protein-protein Interactions for HNRNPU
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDKN2AIP Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXW11 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPD Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait MRPL50 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SART3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXW11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRMT8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HNRNPU
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members SAP_dom IPR003034 1.96
Category members Zeta_toxin_domain IPR010488 0.33
Category members B30.2/SPRY IPR001870 0
Category members SPRY_dom IPR003877 0
Category members ConA-like_lec_gl_sf IPR008985 0


Protein complexes (CORUM database) featuring HNRNPU
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF
Category members Corum 1335 SNW1 complex Database 3.59
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 5611 Emerin complex 24 Database 1.05
Category members Corum 5615 Emerin complex 52 Database 0.99
Category members Corum 1332 Large Drosha complex Database 0.08
Category members Corum 3082 DGCR8 multiprotein complex Database 0.07
Category members Corum 5363 Actin-ribonucleoprotein complex (POLR2A, GTF2F1, HNRNPU) Database 0.06
Category members Corum 4216 GR-hnRNP U complex Database 0


Categories featuring HNRNPU
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0070934 CRD-mediated mRNA stabilization Database 0.7
Category members GO Category GO:0070937 CRD-mediated mRNA stability complex Database 0.44
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0006396 RNA processing Database 0.17
Category members Disease phenotype Epileptic_encephalopathy Epileptic encephalopathy Database 0


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