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Query: HLCS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HLCS 1 2.818 -1.940 3.470

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HLCS Phosphorylation S124 -0.164 -0.488 _FAS(ph)AENIPDLPYDYSSSLESVADETSPER_
HLCS Phosphorylation S147 -0.852 -0.599 _FASAENIPDLPYDYSSSLESVADETS(ph)PER_

Background Information for HLCS:


Pubmed-HLCS »
Uniprot-HLCS »
Biogrid-HLCS »
ProteomicsDB-HLCS »

Tumorportal-HLCS »
COSMIC-HLCS »
GenomeRNAi-HLCS »
Genecards-HLCS


Protein-protein Interactions for HLCS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C1orf111 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLCS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM146 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HLCS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BPL_LipA_LipB IPR004143 0


Protein complexes (CORUM database) featuring HLCS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HLCS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0005652 nuclear lamina Database 1.08
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0009374 biotin binding Database 0.3
Category members GO Category GO:0006767 water-soluble vitamin metabolic process Database 0.27
Category members GO Category GO:0006766 vitamin metabolic process Database 0.23
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0006768 biotin metabolic process Database 0.02
Category members GO Category GO:0006464 cellular protein modification process Database 0
Category members GO Category GO:0016570 histone modification Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0070781 response to biotin Database 0


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