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Query: HIST4H4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HIST4H4 1 5.381 -2.130 2.930 -0.460 0.103 0.645

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HIST4H4 Phosphorylation S48 0.771 1.152 _RIS(ph)GLIYEETR_
HIST4H4 Ubiquitylation K32 0.024 -0.089 _VLRDNIQGITK(gl)PAIR_
HIST4H4 Ubiquitylation K78 0.044 -0.754 _DAVTYTEHAK(gl)R_
HIST4H4 Ubiquitylation K80 0.178 _DAVTYTEHAKRK(gl)_
HIST4H4 Ubiquitylation K92 0.432 _TVTAMDVVYALK(gl)R_

Background Information for HIST4H4:


Pubmed-HIST4H4 »
Uniprot-HIST4H4 »
Biogrid-HIST4H4 »
ProteomicsDB-HIST4H4 »

Tumorportal-HIST4H4 »
COSMIC-HIST4H4 »
GenomeRNAi-HIST4H4 »
Genecards-HIST4H4


Protein-protein Interactions for HIST4H4
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in HIST4H4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Histone_H4 IPR001951 1.02
Category members TAF_TATA-bd IPR004823 0.32
Category members Histone_core_D IPR007125 0.12
Category members Histone-fold IPR009072 0.01


Protein complexes (CORUM database) featuring HIST4H4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1223 H2AX complex, isolated from cells without IR exposure Database 8.51
Category members Corum 1227 H2AX complex II Database 7.93
Category members Corum 3137 MASH1 promoter-coactivator complex Database 5.32


Categories featuring HIST4H4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_351 REACTOME_RNA_POL_I_TRANSCRIPTION 0 8.31
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0006325 chromatin organization Database 5.02
Category members GO Category GO:0045653 negative regulation of megakaryocyte differentiation Database 4.97
Category members GO Category GO:0034080 CENP-A containing nucleosome assembly at centromere Database 4.75
Category members Pathway Pathway_1281 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE 0 4.19
Category members Pathway Pathway_1312 REACTOME_PACKAGING_OF_TELOMERE_ENDS 0 4.09
Category members GO Category GO:0006334 nucleosome assembly Database 3.77
Category members GO Category GO:0006352 DNA-dependent transcription, initiation Database 3.76
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members Pathway Pathway_1139 REACTOME_RNA_POL_I_PROMOTER_OPENING 0 3.56
Category members GO Category GO:0000786 nucleosome Database 2.41
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_889 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0 0.9
Category members Pathway Pathway_920 REACTOME_AMYLOIDS 0 0.68
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28


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