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Query: HERC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HERC1 3 12.642 -1.750 2.210

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HERC1 Ubiquitylation K2769 0.446 2.108 _QIAK(gl)AMEATGAR_
HERC1 Phosphorylation S1428 0.599 2.067 _RVS(ph)TDLPEGQDVYTAACNSVIHR_
HERC1 Ubiquitylation K2881 0.928 1.146 _HK(gl)FDLAAR_
HERC1 Phosphorylation S2720 0.776 0.232 _RQS(ph)LTSPDSQSAR_
HERC1 Ubiquitylation K3837 0.055 _TALK(gl)QQGVLGLNMAPCMR_
HERC1 Ubiquitylation K4462 -1.280 -0.797 _SIGK(gl)TMVQGK_
HERC1 Ubiquitylation K3355 0.181 _LRPNYDK(gl)SEVEK_
HERC1 Phosphorylation S4393 5.329 _EVS(ph)IHTVRAR_

Background Information for HERC1:


Pubmed-HERC1 »
Uniprot-HERC1 »
Biogrid-HERC1 »
ProteomicsDB-HERC1 »

Tumorportal-HERC1 »
COSMIC-HERC1 »
GenomeRNAi-HERC1 »
Genecards-HERC1


Protein-protein Interactions for HERC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MIS12 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLAIN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait C1orf87 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC65 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSNK1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ECHS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FMO5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GCNT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IFIT1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MORC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEUROG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RABGEF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAPGEF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMOX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSH3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFDP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TIGD6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPTE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRPC4AP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VPS36 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDFY3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBBX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF223 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF555 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF563 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF571 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF610 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HERC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members RCC1/BLIP-II IPR009091 0.24
Category members Reg_chr_condens IPR000408 0.23
Category members UBA-like IPR009060 0.17
Category members HECT IPR000569 0.04
Category members B30.2/SPRY IPR001870 0
Category members SPRY_dom IPR003877 0
Category members ConA-like_lec_gl_sf IPR008985 0


Protein complexes (CORUM database) featuring HERC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HERC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members GO Category GO:0050885 neuromuscular process controlling balance Database 0.02
Category members GO Category GO:0005086 ARF guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0010507 negative regulation of autophagy Database 0
Category members GO Category GO:0021702 cerebellar Purkinje cell differentiation Database 0


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