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Query: HADHA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HADHA 1 3.206 -1.770 3.360 0.007 -0.956 -0.181 0.499 0.477

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for HADHA:


Pubmed-HADHA »
Uniprot-HADHA »
Biogrid-HADHA »
ProteomicsDB-HADHA »

Tumorportal-HADHA »
COSMIC-HADHA »
GenomeRNAi-HADHA »
Genecards-HADHA


Protein-protein Interactions for HADHA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYC Cat. description Hein, Mann, Cell 2015
Category members IP bait NAF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HADHB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RELL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HADHA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members 6-PGluconate_DH_C-like IPR008927 0.51
Category members Crotonase_core_superfam IPR001753 0.08
Category members ClpP/crotonase-like_dom IPR029045 0.08
Category members 3HC_DH_C IPR006108 0.04
Category members 3-OHacyl-CoA_DH_NAD-bd IPR006176 0.04


Protein complexes (CORUM database) featuring HADHA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HADHA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_28 KEGG_PROPANOATE_METABOLISM 0 1.89
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0051287 NAD binding Database 1.6
Category members Pathway Pathway_136 KEGG_LIMONENE_AND_PINENE_DEGRADATION 0 0.87
Category members Pathway Pathway_22 KEGG_LYSINE_DEGRADATION 0 0.8
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0042645 mitochondrial nucleoid Database 0.61
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_134 KEGG_BETA_ALANINE_METABOLISM 0 0.49
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_133 KEGG_FATTY_ACID_METABOLISM 0 0.31
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members Pathway Pathway_144 KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS 0 0.13
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Pathway Pathway_37 KEGG_TRYPTOPHAN_METABOLISM 0 0.06
Category members Pathway Pathway_145 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION 0 0.05
Category members Pathway Pathway_19 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION 0 0.04
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_161 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_46 KEGG_BUTANOATE_METABOLISM 0 0
Category members Disease phenotype Mitochondrial_trifunctional_protein_deficiency Mitochondrial trifunctional protein deficiency Database 0
Category members Disease phenotype TRIFUNCTIONAL_PROTEIN_DEFICIENCY TRIFUNCTIONAL PROTEIN DEFICIENCY Database 0
Category members GO Category GO:0000062 fatty-acyl-CoA binding Database 0
Category members GO Category GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity Database 0
Category members GO Category GO:0003985 acetyl-CoA C-acetyltransferase activity Database 0
Category members GO Category GO:0003988 acetyl-CoA C-acyltransferase activity Database 0
Category members GO Category GO:0004300 enoyl-CoA hydratase activity Database 0
Category members GO Category GO:0006631 fatty acid metabolic process Database 0
Category members GO Category GO:0006635 fatty acid beta-oxidation Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex Database 0
Category members GO Category GO:0016508 long-chain-enoyl-CoA hydratase activity Database 0
Category members GO Category GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0035965 cardiolipin acyl-chain remodeling Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0046474 glycerophospholipid biosynthetic process Database 0
Category members GO Category GO:0050662 coenzyme binding Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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