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Query: GOT1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GOT1 0 -0.470 -0.320 0.110

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GOT1 Ubiquitylation K97 -0.580 _LALGDDSPALK(gl)EK_

Background Information for GOT1:


Pubmed-GOT1 »
Uniprot-GOT1 »
Biogrid-GOT1 »
ProteomicsDB-GOT1 »

Tumorportal-GOT1 »
COSMIC-GOT1 »
GenomeRNAi-GOT1 »
Genecards-GOT1


Protein-protein Interactions for GOT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GOT1L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GOT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Asp_trans IPR000796 0.05
Category members Aminotransferase_I/II IPR004839 0
Category members PyrdxlP-dep_Trfase IPR015424 0


Protein complexes (CORUM database) featuring GOT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GOT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members GO Category GO:0006094 gluconeogenesis Database 1.42
Category members Pathway Pathway_33 REACTOME_GLUCONEOGENESIS 0 1.41
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members GO Category GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Database 0.26
Category members GO Category GO:0006532 aspartate biosynthetic process Database 0.26
Category members GO Category GO:0019550 glutamate catabolic process to aspartate Database 0.26
Category members GO Category GO:0019551 glutamate catabolic process to 2-oxoglutarate Database 0.26
Category members GO Category GO:0043648 dicarboxylic acid metabolic process Database 0.26
Category members GO Category GO:0006533 aspartate catabolic process Database 0.23
Category members GO Category GO:0006531 aspartate metabolic process Database 0.2
Category members GO Category GO:0000096 sulfur amino acid metabolic process Database 0.15
Category members GO Category GO:0055089 fatty acid homeostasis Database 0.14
Category members GO Category GO:0009058 biosynthetic process Database 0.11
Category members GO Category GO:0004609 phosphatidylserine decarboxylase activity Database 0.08
Category members GO Category GO:0006114 glycerol biosynthetic process Database 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members Pathway Pathway_400 KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 0 0.04
Category members Pathway Pathway_272 KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 0 0.04
Category members GO Category GO:0034641 cellular nitrogen compound metabolic process Database 0.01
Category members GO Category GO:0006536 glutamate metabolic process Database 0.01
Category members Pathway Pathway_135 KEGG_ARGININE_AND_PROLINE_METABOLISM 0 0.01
Category members Pathway Pathway_154 KEGG_TYROSINE_METABOLISM 0 0
Category members Pathway Pathway_17 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 0 0
Category members Pathway Pathway_394 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION 0 0
Category members Pathway Pathway_398 KEGG_PHENYLALANINE_METABOLISM 0 0
Category members Pathway Pathway_399 REACTOME_SULFUR_AMINO_ACID_METABOLISM 0 0
Category members Pathway Pathway_401 REACTOME_METABOLISM_OF_POLYAMINES 0 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0006103 2-oxoglutarate metabolic process Database 0
Category members GO Category GO:0006107 oxaloacetate metabolic process Database 0
Category members GO Category GO:0006520 cellular amino acid metabolic process Database 0
Category members GO Category GO:0006595 polyamine metabolic process Database 0
Category members GO Category GO:0008483 transaminase activity Database 0
Category members GO Category GO:0008652 cellular amino acid biosynthetic process Database 0
Category members GO Category GO:0019509 L-methionine salvage from methylthioadenosine Database 0
Category members GO Category GO:0030170 pyridoxal phosphate binding Database 0
Category members GO Category GO:0031406 carboxylic acid binding Database 0
Category members GO Category GO:0043679 axon terminus Database 0


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