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Query: GCLM

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GCLM 0 -0.760 0.680 -0.230

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GCLM Ubiquitylation K90 -0.531 -0.229 _INPDEREEMK(gl)VSAK_

Background Information for GCLM:


Pubmed-GCLM »
Uniprot-GCLM »
Biogrid-GCLM »
ProteomicsDB-GCLM »

Tumorportal-GCLM »
COSMIC-GCLM »
GenomeRNAi-GCLM »
Genecards-GCLM


Protein-protein Interactions for GCLM
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GCLC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PARP12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLAUR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKCA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRPV5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UROS Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GCLM
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NADP_OxRdtase_dom IPR023210 0


Protein complexes (CORUM database) featuring GCLM
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GCLM
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0006750 glutathione biosynthetic process Database 0.25
Category members GO Category GO:0000096 sulfur amino acid metabolic process Database 0.15
Category members GO Category GO:0034641 cellular nitrogen compound metabolic process Database 0.01
Category members GO Category GO:0006536 glutamate metabolic process Database 0.01
Category members GO Category GO:0008637 apoptotic mitochondrial changes Database 0.01
Category members Pathway Pathway_17 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 0 0
Category members Pathway Pathway_27 KEGG_GLUTATHIONE_METABOLISM 0 0
Category members Pathway Pathway_399 REACTOME_SULFUR_AMINO_ACID_METABOLISM 0 0
Category members Pathway Pathway_452 REACTOME_GLUTATHIONE_CONJUGATION 0 0
Category members Pathway Pathway_82 REACTOME_PHASE_II_CONJUGATION 0 0
Category members Pathway Pathway_85 REACTOME_BIOLOGICAL_OXIDATIONS 0 0
Category members GO Category GO:0004357 glutamate-cysteine ligase activity Database 0
Category members GO Category GO:0006534 cysteine metabolic process Database 0
Category members GO Category GO:0006749 glutathione metabolic process Database 0
Category members GO Category GO:0006805 xenobiotic metabolic process Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0017109 glutamate-cysteine ligase complex Database 0
Category members GO Category GO:0050880 regulation of blood vessel size Database 0
Category members GO Category GO:0051409 response to nitrosative stress Database 0
Category members GO Category GO:0051900 regulation of mitochondrial depolarization Database 0


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