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Query: FH

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FH 0 1.965 1.300 -0.210 1.313 0.652

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for FH:


Pubmed-FH »
Uniprot-FH »
Biogrid-FH »
ProteomicsDB-FH »

Tumorportal-FH »
COSMIC-FH »
GenomeRNAi-FH »
Genecards-FH


Protein-protein Interactions for FH
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in FH
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members L-Aspartase-like IPR008948 0.04
Category members Fumarate_lyase_fam IPR000362 0
Category members Fumarate_lyase_N IPR022761 0


Protein complexes (CORUM database) featuring FH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_3 KEGG_CITRATE_CYCLE_TCA_CYCLE 0 3.83
Category members GO Category GO:0006099 tricarboxylic acid cycle Database 2.74
Category members Pathway Pathway_12 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE 0 1.87
Category members Pathway Pathway_10 REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE 0 1.76
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_8 BIOCARTA_KREB_PATHWAY 0 1.35
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members GO Category GO:0048873 homeostasis of number of cells within a tissue Database 0.04
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Disease phenotype Hereditary_pheochromocytoma-paraganglioma Hereditary pheochromocytoma-paraganglioma Database 0
Category members GO Category GO:0016829 lyase activity Database 0


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