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Query: FGB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FGB 0 -4.320 0.920 -1.250 -4.320

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for FGB:


Pubmed-FGB »
Uniprot-FGB »
Biogrid-FGB »
ProteomicsDB-FGB »

Tumorportal-FGB »
COSMIC-FGB »
GenomeRNAi-FGB »
Genecards-FGB


Protein-protein Interactions for FGB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ALDH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASCC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNYL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX19B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BJ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPK6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RING1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM237 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FGB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Fibrinogen_a/b/g_coil_dom IPR012290 0.14
Category members Fibrinogen_a/b/g_C_dom IPR002181 0


Protein complexes (CORUM database) featuring FGB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FGB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0051087 chaperone binding Database 1.69
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0030674 protein binding, bridging Database 0.25
Category members Pathway Pathway_710 PID_UPA_UPAR_PATHWAY 0 0.2
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Disease phenotype AFIBRINOGENEMIA_CONGENITAL AFIBRINOGENEMIA CONGENITAL Database 0.14
Category members Disease phenotype Familial_afibrinogenemia Familial afibrinogenemia Database 0.14
Category members Disease phenotype Familial_dysfibrinogenemia Familial dysfibrinogenemia Database 0.14
Category members Disease phenotype Familial_hypodysfibrinogenemia Familial hypodysfibrinogenemia Database 0.14
Category members Disease phenotype Familial_hypofibrinogenemia Familial hypofibrinogenemia Database 0.14
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_932 REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 0 0.01
Category members GO Category GO:0005577 fibrinogen complex Database 0.01
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_1231 REACTOME_COMMON_PATHWAY 0 0
Category members Pathway Pathway_1027 PID_INTEGRIN1_PATHWAY 0 0
Category members Pathway Pathway_1060 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS 0 0
Category members Pathway Pathway_1109 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ 0 0
Category members Pathway Pathway_1189 KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 0 0
Category members Pathway Pathway_1194 BIOCARTA_AMI_PATHWAY 0 0
Category members Pathway Pathway_1195 BIOCARTA_EXTRINSIC_PATHWAY 0 0
Category members Pathway Pathway_1196 BIOCARTA_INTRINSIC_PATHWAY 0 0
Category members Pathway Pathway_1197 BIOCARTA_FIBRINOLYSIS_PATHWAY 0 0
Category members Pathway Pathway_1219 PID_INTEGRIN2_PATHWAY 0 0
Category members Pathway Pathway_1232 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE 0 0
Category members Pathway Pathway_547 PID_EPHRINB_REV_PATHWAY 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_740 PID_INTEGRIN3_PATHWAY 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members Pathway Pathway_931 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 0 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0031091 platelet alpha granule Database 0
Category members GO Category GO:0031093 platelet alpha granule lumen Database 0
Category members GO Category GO:0044320 cellular response to leptin stimulus Database 0
Category members GO Category GO:0051258 protein polymerization Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0071347 cellular response to interleukin-1 Database 0


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