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Query: FBXW5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FBXW5 0 -0.095 0.640 -0.720

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FBXW5 Ubiquitylation K240 0.526 _LFK(gl)IQNLNASTVR_
FBXW5 Phosphorylation S275 -0.621 _FDSPDLLLEAGDPATS(ph)PCR_
FBXW5 Ubiquitylation K337 -1.751 _VAELLAQGHTK(gl)PPER_

Background Information for FBXW5:


Pubmed-FBXW5 »
Uniprot-FBXW5 »
Biogrid-FBXW5 »
ProteomicsDB-FBXW5 »

Tumorportal-FBXW5 »
COSMIC-FBXW5 »
GenomeRNAi-FBXW5 »
Genecards-FBXW5


Protein-protein Interactions for FBXW5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SKP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DEFB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPB9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDEL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEFM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ODF3L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRFBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSNAXIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF704 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNRF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FBXW5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members F-box_dom IPR001810 0
Category members Quinoprot_gluc/sorb_DH IPR011041 0


Protein complexes (CORUM database) featuring FBXW5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FBXW5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_742 REACTOME_PROTEIN_FOLDING 0 0.9
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_741 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS 0 0.29
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0019005 SCF ubiquitin ligase complex Database 0.09
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Database 0.05
Category members GO Category GO:0051298 centrosome duplication Database 0


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