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Query: ESPL1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ESPL1 0 -5.393 0.260 0.370

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ESPL1 Ubiquitylation K1252 -0.245 _VLQSGLK(gl)FVAAR_
ESPL1 Ubiquitylation K593 -0.279 _EELQAYK(gl)AVR_
ESPL1 Ubiquitylation K515 -0.310 _LQVESLK(gl)K_
ESPL1 Ubiquitylation K516 -0.310 _LQVESLK(gl)K_
ESPL1 Ubiquitylation K64 -0.593 _ACNQQLTAK(gl)LACPR_
ESPL1 Ubiquitylation K760 -0.694 _ELLTK(gl)GQAPAVR_
ESPL1 Ubiquitylation K1832 -1.682 -1.025 _LQELLQDCGWK(gl)YPDR_
ESPL1 Ubiquitylation K567 -1.164 _AGDKELQLK(gl)TLR_
ESPL1 Phosphorylation S1126 -1.840 -1.996 _EPGPIAPSTNSS(ph)PVLK_

Background Information for ESPL1:


Pubmed-ESPL1 »
Uniprot-ESPL1 »
Biogrid-ESPL1 »
ProteomicsDB-ESPL1 »

Tumorportal-ESPL1 »
COSMIC-ESPL1 »
GenomeRNAi-ESPL1 »
Genecards-ESPL1


Protein-protein Interactions for ESPL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CXCR7 Cat. description Hein, Mann, Cell 2015
Category members IP bait ESPL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXO7 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPD Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait IBTK Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF19 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF2C Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPH Cat. description Hein, Mann, Cell 2015
Category members IP bait PTTG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SGTB Cat. description Hein, Mann, Cell 2015
Category members IP bait TTK Cat. description Hein, Mann, Cell 2015
Category members IP bait TTLL7 Cat. description Hein, Mann, Cell 2015
Category members IP bait USP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM46A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FUZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GFOD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IARS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYPD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTTG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TULP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ESPL1
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring ESPL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5642 Securin-separase complex Database 0.31
Category members Corum 5643 ESPL1-CDC2 complex Database 0.31


Categories featuring ESPL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0040001 establishment of mitotic spindle localization Database 0.31
Category members GO Category GO:0000910 cytokinesis Database 0.15
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0007127 meiosis I Database 0.02
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members GO Category GO:0000070 mitotic sister chromatid segregation Database 0
Category members GO Category GO:0000212 meiotic spindle organization Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0008234 cysteine-type peptidase activity Database 0
Category members GO Category GO:0045143 homologous chromosome segregation Database 0
Category members GO Category GO:0045842 positive regulation of mitotic metaphase/anaphase transition Database 0
Category members GO Category GO:0045875 negative regulation of sister chromatid cohesion Database 0


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