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Query: EPS15L1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EPS15L1 0 2.111 0.060 -0.480 -0.187 0.065

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EPS15L1 Ubiquitylation K531 0.195 0.973 _VQLETIIK(gl)SLK_
EPS15L1 Phosphorylation T612 0.698 _ALLFSNNT(ph)QELHPDPFQTEDPFK_
EPS15L1 Ubiquitylation K534 -0.080 0.668 _SLK(gl)STQDEINQAR_
EPS15L1 Ubiquitylation K679 0.297 0.644 _GSATDDFFK(gl)K_
EPS15L1 Ubiquitylation K546 -0.181 0.567 _SK(gl)LSQLHESR_
EPS15L1 Phosphorylation S575 0.556 _SLEQYDQVLDGAHGAS(ph)LTDLANLSEGVSLAER_
EPS15L1 Phosphorylation T577 0.556 _SLEQYDQVLDGAHGAS(ph)LTDLANLSEGVSLAER_
EPS15L1 Ubiquitylation K604 -0.465 0.502 _GSFGAMDDPFKNK(gl)_
EPS15L1 Phosphorylation S255 0.126 0.287 _STPSHGSVSSLNSTGSLS(ph)PK_
EPS15L1 Ubiquitylation K492 -0.067 0.278 _TQIQSQESDLK(gl)SQEDDLNR_
EPS15L1 Ubiquitylation K683 -0.669 -0.149 _QTK(gl)NDPFTSDPFTK_
EPS15L1 Phosphorylation S107 -0.485 -0.667 _FHDTS(ph)SPLM(ox)VTPPSAEAHWAVR_
EPS15L1 Phosphorylation S229 -1.124 -1.213 _KTVFPGAVPVLPAS(ph)PPPKDSLR_
EPS15L1 Ubiquitylation K694 -2.706 -1.303 _NDPFTSDPFTK(gl)NPSLPSK_
EPS15L1 Ubiquitylation K400 0.435 _EK(gl)YSLEQDIR_
EPS15L1 Ubiquitylation K701 -2.391 _NPSLPSK(gl)LDPFESSDPFSSSSVSSK_
EPS15L1 Phosphorylation S804 -1.633 _STPVSQLGS(ph)ADFPEAPDPFQPLGADSGDPFQSK_

Background Information for EPS15L1:


Pubmed-EPS15L1 »
Uniprot-EPS15L1 »
Biogrid-EPS15L1 »
ProteomicsDB-EPS15L1 »

Tumorportal-EPS15L1 »
COSMIC-EPS15L1 »
GenomeRNAi-EPS15L1 »
Genecards-EPS15L1


Protein-protein Interactions for EPS15L1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIAA1107 Cat. description Hein, Mann, Cell 2015
Category members IP bait ODF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait OTUD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait PLK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCHO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCKIPSD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUNDC3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPC25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EPS15L1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-int_motif IPR003903 0.49
Category members EPS15_homology IPR000261 0
Category members EF_hand_dom IPR002048 0
Category members Prefoldin IPR009053 0


Protein complexes (CORUM database) featuring EPS15L1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EPS15L1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_809 REACTOME_EGFR_DOWNREGULATION 0 1.1
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0005509 calcium ion binding Database 0.11


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