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Query: EIF4A3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF4A3 2 5.804 -1.590 2.620 0.070 0.033 0.220 -0.539 -0.195

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF4A3 Phosphorylation T163 0.454 _KLDYGQHVVAGT(ph)PGR_
EIF4A3 Ubiquitylation K321 0.578 0.367 _ESIMK(gl)EFR_
EIF4A3 Phosphorylation S12 -0.433 0.298 _(ac)ATTATMATSGS(ph)AR_
EIF4A3 Phosphorylation S10 1.817 _(ac)ATTATM(ox)ATS(ph)GSARK_
EIF4A3 Ubiquitylation K314 0.119 _EANFTVSSMHGDMPQK(gl)ER_
EIF4A3 Ubiquitylation K374 0.958 _K(gl)GVAINFVK_

Background Information for EIF4A3:


Pubmed-EIF4A3 »
Uniprot-EIF4A3 »
Biogrid-EIF4A3 »
ProteomicsDB-EIF4A3 »

Tumorportal-EIF4A3 »
COSMIC-EIF4A3 »
GenomeRNAi-EIF4A3 »
Genecards-EIF4A3


Protein-protein Interactions for EIF4A3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC9 Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM8A Cat. description Hein, Mann, Cell 2015
Category members IP bait SART3 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBA6 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZBTB48 Cat. description Hein, Mann, Cell 2015
Category members IP bait C11orf57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SARNP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VTI1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF4A3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members RNA_helicase_DEAD_Q_motif IPR014014 0.24


Protein complexes (CORUM database) featuring EIF4A3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 785 Exon junction complex Database 0.29
Category members Corum 740 Exon junction complex, EIF4A3-MLN51-MAGOH-Y14 (RNA-protein complex) Database 0
Category members Corum 744 Exon junction complex (EIF4A3-MLN51-MAGOH-Y14) Database 0
Category members Corum 754 Exon junction complex (EIF4A3-MLN51-UPF3B-MAGOH-Y14) Database 0
Category members Corum 755 Exon junction complex (F4A3-MLN51-UPF3B-MAGOH-Y14-PYM) Database 0
Category members Corum 769 Exon junction complex (EIF4A3-MLN51-MAGOH-Y14), RNA-protein complex Database 0
Category members Corum 772 eIF4AIII-Btz complex Database 0


Categories featuring EIF4A3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_770 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0006364 rRNA processing Database 2.47
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0051028 mRNA transport Database 1.7
Category members GO Category GO:0004004 ATP-dependent RNA helicase activity Database 1.43
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0008143 poly(A) RNA binding Database 0.44
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0035145 exon-exon junction complex Database 0.28
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members GO Category GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening Database 0.06
Category members Pathway Pathway_841 REACTOME_DEADENYLATION_OF_MRNA 0 0
Category members GO Category GO:0045727 positive regulation of translation Database 0


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