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Query: EIF2B3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF2B3 0 -1.455 1.580 -0.430 -3.615 1.427 1.157

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF2B3 Ubiquitylation K61 -0.836 -0.162 _DVQK(gl)ALCAEFK_
EIF2B3 Ubiquitylation K382 -0.991 -0.264 _SVIGSSCLIK(gl)DR_
EIF2B3 Ubiquitylation K165 -0.262 -0.491 _DFIGVDSTGK(gl)R_
EIF2B3 Ubiquitylation K68 -0.565 _ALCAEFK(gl)MK_
EIF2B3 Ubiquitylation K148 -1.168 -1.682 _KGQDSIEPVPGQKGK(gl)_

Background Information for EIF2B3:


Pubmed-EIF2B3 »
Uniprot-EIF2B3 »
Biogrid-EIF2B3 »
ProteomicsDB-EIF2B3 »

Tumorportal-EIF2B3 »
COSMIC-EIF2B3 »
GenomeRNAi-EIF2B3 »
Genecards-EIF2B3


Protein-protein Interactions for EIF2B3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC42 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZWINT Cat. description Hein, Mann, Cell 2015
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CA14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ECH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF2B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF2B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPHA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZD10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR183 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GYPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RX4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTGER3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVRL4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM206 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VTI1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF2B3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Nucleotide-diphossugar_trans IPR029044 0.21
Category members NTP_transferase IPR005835 0.04
Category members Trimer_LpxA-like IPR011004 0


Protein complexes (CORUM database) featuring EIF2B3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EIF2B3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0008135 translation factor activity, nucleic acid binding Database 0.53
Category members GO Category GO:0014003 oligodendrocyte development Database 0.21
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0009058 biosynthetic process Database 0.11
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members Disease phenotype Cree_leukoencephalopathy Cree leukoencephalopathy Database 0
Category members Disease phenotype Late_infantile_CACH_syndrome Late infantile CACH syndrome Database 0
Category members Disease phenotype LEUKOENCEPHALOPATHY_WITH_VANISHING_WHITE_MATTER LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER Database 0
Category members Disease phenotype OVARIOLEUKODYSTROPHY OVARIOLEUKODYSTROPHY Database 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0005851 eukaryotic translation initiation factor 2B complex Database 0
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0009408 response to heat Database 0
Category members GO Category GO:0016779 nucleotidyltransferase activity Database 0
Category members GO Category GO:0032057 negative regulation of translational initiation in response to stress Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0051716 cellular response to stimulus Database 0


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