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Query: EIF1AX

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF1AX 0 3.198 0.722 0.019 0.663

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF1AX Ubiquitylation K56 0.668 1.126 _LEAM(ox)CFDGVK(gl)R_
EIF1AX Ubiquitylation K94 0.441 1.037 _DYQDNKADVILK(gl)YNADEAR_
EIF1AX Ubiquitylation K29 0.235 0.769 _ELVFK(gl)EDGQEYAQVIK_
EIF1AX Ubiquitylation K88 -0.210 0.111 _DYQDNK(gl)ADVILK_
EIF1AX Ubiquitylation K104 0.257 0.111 _SLK(gl)AYGELPEHAK_

Background Information for EIF1AX:


Pubmed-EIF1AX »
Uniprot-EIF1AX »
Biogrid-EIF1AX »
ProteomicsDB-EIF1AX »

Tumorportal-EIF1AX »
COSMIC-EIF1AX »
GenomeRNAi-EIF1AX »
Genecards-EIF1AX


Protein-protein Interactions for EIF1AX
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CRHBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKFZp686O24166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF1AY Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POF1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WFDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF1AX
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members TIF_eIF-1A IPR001253 0.06
Category members RNA-binding_domain_S1_IF1 IPR006196 0.06


Protein complexes (CORUM database) featuring EIF1AX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1551 IPO13-RAN-EIF1AX complex Database 0.08


Categories featuring EIF1AX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_769 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_1274 BIOCARTA_EIF_PATHWAY 0 0.78
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0008135 translation factor activity, nucleic acid binding Database 0.53
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0


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