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Query: EDC4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EDC4 0 3.988 1.140 -0.850 1.220 0.146 0.040

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EDC4 Phosphorylation S741 0.242 1.055 _T(ph)RSPDVISSASTALS(ph)QDIPEIASEALSR_
EDC4 Phosphorylation S879 0.781 0.805 _DSQDASAEQS(ph)DHDDEVASLASASGGFGTK_
EDC4 Phosphorylation S844 -0.222 0.517 _ETCSTLAES(ph)PR_
EDC4 Phosphorylation S6 0.694 0.508 _(ac)ASCAS(ph)IDIEDATQHLR_
EDC4 Phosphorylation T727 0.284 0.193 _T(ph)RSPDVISSASTALSQDIPEIASEALSR_
EDC4 Phosphorylation S729 -0.039 0.192 _S(ph)PDVISSASTALSQDIPEIASEALSR_
EDC4 Phosphorylation S723 -0.821 -0.217 _GPGQVPTATSALSLELQEVEPLGLPQAS(ph)PSR_
EDC4 Phosphorylation S780 -0.253 _GFGSSAPEGLEPDSMASAASALHLLS(ph)PRPR_
EDC4 Phosphorylation S725 -0.736 -0.860 _GPGQVPTATSALSLELQEVEPLGLPQAS(ph)PSR_
EDC4 Ubiquitylation K111 0.746 _EVEIVASSDSSISSK(gl)AR_
EDC4 Phosphorylation S734 0.095 _TRS(ph)PDVIS(ph)SASTALSQDIPEIASEALSR_

Background Information for EDC4:


Pubmed-EDC4 »
Uniprot-EDC4 »
Biogrid-EDC4 »
ProteomicsDB-EDC4 »

Tumorportal-EDC4 »
COSMIC-EDC4 »
GenomeRNAi-EDC4 »
Genecards-EDC4


Protein-protein Interactions for EDC4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC101 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait CRKL Cat. description Hein, Mann, Cell 2015
Category members IP bait DCP1A Cat. description Hein, Mann, Cell 2015
Category members IP bait EDC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF11 Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1R35 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BSG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C4orf3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC101 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EDC4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52


Protein complexes (CORUM database) featuring EDC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 559 Decapping complex Database 0.05


Categories featuring EDC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members GO Category GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Database 0.21
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members GO Category GO:0000932 cytoplasmic mRNA processing body Database 0.08
Category members Pathway Pathway_843 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE 0 0
Category members GO Category GO:0008150 biological_process Database 0


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