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Query: DHX9

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DHX9 0 -5.421 0.160 -0.600 -0.456 -0.799 -0.169

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DHX9 Ubiquitylation K467 0.273 0.693 _GEEPGK(gl)SCGYSVR_
DHX9 Ubiquitylation K146 0.085 0.291 _GANLK(gl)DYYSR_
DHX9 Ubiquitylation K1024 0.044 -0.110 _NALIHK(gl)SSVNCPFSSQDMK_
DHX9 Ubiquitylation K193 -0.204 _LNQYFQK(gl)EK_
DHX9 Ubiquitylation K857 -0.156 -0.205 _ILAK(gl)LPIEPR_
DHX9 Ubiquitylation K497 0.228 -0.210 _K(gl)LEAGIR_
DHX9 Ubiquitylation K191 -0.896 -0.427 _LNQYFQK(gl)EK_
DHX9 Phosphorylation T97 -2.744 _SEEVPAFGVASPPPLTDTPDT(ph)TANAEGDLPTTM(ox)GGPLPPHLALK_
DHX9 Phosphorylation S87 -3.262 -3.196 _SEEVPAFGVAS(ph)PPPLTDTPDTTANAEGDLPTTMGGPLPPHLALK_
DHX9 Ubiquitylation K16 0.349 _K(gl)MTPSYEIR_
DHX9 Ubiquitylation K1037 0.034 _SSVNCPFSSQDMK(gl)YPSPFFVFGEK_

Background Information for DHX9:


Pubmed-DHX9 »
Uniprot-DHX9 »
Biogrid-DHX9 »
ProteomicsDB-DHX9 »

Tumorportal-DHX9 »
COSMIC-DHX9 »
GenomeRNAi-DHX9 »
Genecards-DHX9


Protein-protein Interactions for DHX9
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FUS Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA3 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP56 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait TAF15 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRMT8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DHX9
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members dsRNA-bd_dom IPR014720 0.23
Category members DUF1605 IPR011709 0.02
Category members Helicase-assoc_dom IPR007502 0


Protein complexes (CORUM database) featuring DHX9
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 924 Toposome Database 0.88
Category members Corum 3102 DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex Database 0.44
Category members Corum 3082 DGCR8 multiprotein complex Database 0.07
Category members Corum 3618 GammaH2AFX-NDHII-Ku70-DNA complex Database 0.06
Category members Corum 1749 SMN-PolII-RHA complex Database 0
Category members Corum 3129 STAT6-p100-RHA complex Database 0


Categories featuring DHX9
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0004004 ATP-dependent RNA helicase activity Database 1.43
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0070934 CRD-mediated mRNA stabilization Database 0.7
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members GO Category GO:0070937 CRD-mediated mRNA stability complex Database 0.44
Category members GO Category GO:0034605 cellular response to heat Database 0.18
Category members GO Category GO:0003724 RNA helicase activity Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0001085 RNA polymerase II transcription factor binding Database 0
Category members GO Category GO:0007623 circadian rhythm Database 0


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