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Query: DHFR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DHFR 0 2.321 -1.520 2.470 -0.938 -0.400

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DHFR Ubiquitylation K56 -0.219 _QNLVIMGK(gl)K_
DHFR Ubiquitylation K55 -0.547 _QNLVIMGK(gl)K_
DHFR Ubiquitylation K158 -1.504 _YK(gl)LLPEYPGVLSDVQEEK_
DHFR Ubiquitylation K81 -1.954 _ELK(gl)EPPQGAHFLSR_
DHFR Ubiquitylation K99 -2.021 _SLDDALK(gl)LTEQPELANK_
DHFR Ubiquitylation K174 -2.693 _LLPEYPGVLSDVQEEK(gl)GIK_
DHFR Ubiquitylation K133 1.408 _EAM(ox)NHPGHLK(gl)LFVTR_

Background Information for DHFR:


Pubmed-DHFR »
Uniprot-DHFR »
Biogrid-DHFR »
ProteomicsDB-DHFR »

Tumorportal-DHFR »
COSMIC-DHFR »
GenomeRNAi-DHFR »
Genecards-DHFR


Protein-protein Interactions for DHFR
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in DHFR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DHFR_dom IPR001796 0
Category members DHFR IPR012259 0
Category members DHFR-like_dom IPR024072 0


Protein complexes (CORUM database) featuring DHFR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DHFR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0046653 tetrahydrofolate metabolic process Database 0.91
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_326 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 0 0.49
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members GO Category GO:0006767 water-soluble vitamin metabolic process Database 0.27
Category members GO Category GO:0006766 vitamin metabolic process Database 0.23
Category members Pathway Pathway_279 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS 0 0.18
Category members GO Category GO:0009165 nucleotide biosynthetic process Database 0.17
Category members Pathway Pathway_275 KEGG_ONE_CARBON_POOL_BY_FOLATE 0 0.11
Category members Pathway Pathway_435 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION 0 0
Category members Pathway Pathway_438 REACTOME_ENOS_ACTIVATION_AND_REGULATION 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_746 KEGG_FOLATE_BIOSYNTHESIS 0 0
Category members GO Category GO:0004146 dihydrofolate reductase activity Database 0
Category members GO Category GO:0005575 cellular_component Database 0
Category members GO Category GO:0006545 glycine biosynthetic process Database 0
Category members GO Category GO:0006730 one-carbon metabolic process Database 0
Category members GO Category GO:0008144 drug binding Database 0
Category members GO Category GO:0031427 response to methotrexate Database 0
Category members GO Category GO:0046209 nitric oxide metabolic process Database 0
Category members GO Category GO:0046654 tetrahydrofolate biosynthetic process Database 0
Category members GO Category GO:0046655 folic acid metabolic process Database 0
Category members GO Category GO:0050661 NADP binding Database 0
Category members GO Category GO:0050999 regulation of nitric-oxide synthase activity Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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