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Query: DEK

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DEK 2 8.282 -0.440 0.780 1.393 0.327 0.634 0.738 0.313

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DEK Ubiquitylation K57 1.574 _SLIVEGK(gl)R_
DEK Ubiquitylation K177 1.939 1.451 _SGVNSELVK(gl)R_
DEK Phosphorylation S32 0.303 0.281 _EPEMPGPREES(ph)EEEEDEDDEEEEEEEKEK_
DEK Phosphorylation T13 -0.652 -0.453 _(ac)SASAPAAEGEGT(ph)PTQPASEK_
DEK Ubiquitylation K84 1.492 _EPFTIAQGK(gl)GQK_
DEK Ubiquitylation K125 0.685 _K(gl)NVGQFSGFPFEK_
DEK Ubiquitylation K371 1.418 _TTVK(gl)ELIS_

Background Information for DEK:


Pubmed-DEK »
Uniprot-DEK »
Biogrid-DEK »
ProteomicsDB-DEK »

Tumorportal-DEK »
COSMIC-DEK »
GenomeRNAi-DEK »
Genecards-DEK


Protein-protein Interactions for DEK
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MMGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP56 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015


Protein Domains in DEK
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAP_dom IPR003034 1.96
Category members DEK_C IPR014876 0.16


Protein complexes (CORUM database) featuring DEK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5449 Splicing-associated factors complex Database 0.5


Categories featuring DEK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0042393 histone binding Database 0.94
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0019079 viral genome replication Database 0.22
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0007165 signal transduction Database 0


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