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Query: DDX23

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DDX23 1 4.128 0.090 -0.140
DDX23 1 4.128 0.090 -0.140 0.001 -0.214 0.377 0.541 0.355

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DDX23 Ubiquitylation K259 1.705 1.364 _YLGGIK(gl)K_
DDX23 Ubiquitylation K260 1.705 1.364 _YLGGIK(gl)K_
DDX23 Ubiquitylation K326 -0.482 _FYGDLMEK(gl)R_

Background Information for DDX23:


Pubmed-DDX23 »
Uniprot-DDX23 »
Biogrid-DDX23 »
ProteomicsDB-DDX23 »

Tumorportal-DDX23 »
COSMIC-DDX23 »
GenomeRNAi-DDX23 »
Genecards-DDX23


Protein-protein Interactions for DDX23
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CERK Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4C Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait KIFAP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait SART1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BSG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C2orf3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX23 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DDX23
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members RNA_helicase_DEAD_Q_motif IPR014014 0.24


Protein complexes (CORUM database) featuring DDX23
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1335 SNW1 complex Database 3.59
Category members Corum 1181 C complex spliceosome Database 2.39


Categories featuring DDX23
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_372 REACTOME_MRNA_SPLICING_MINOR_PATHWAY 0 1.52
Category members GO Category GO:0004004 ATP-dependent RNA helicase activity Database 1.43
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0000375 RNA splicing, via transesterification reactions Database 0.73
Category members GO Category GO:0005682 U5 snRNP Database 0.57
Category members GO Category GO:0000354 cis assembly of pre-catalytic spliceosome Database 0.32


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