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Query: DDX17

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DDX17 2 5.254 0.430 0.190
DDX17 2 5.254 0.430 0.190 -0.510 -0.742 -0.115 0.045 0.000

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DDX17 Phosphorylation S680 1.413 3.083 _SSQSSS(ph)QQFSGIGR_
DDX17 Phosphorylation S675 1.927 1.128 _S(ph)SQSSSQQFSGIGR_
DDX17 Ubiquitylation K530 -0.050 0.759 _GTAYTFFTPGNLK(gl)QAR_
DDX17 Ubiquitylation K271 -0.079 0.464 _ELAQQVQQVADDYGK(gl)CSR_
DDX17 Ubiquitylation K197 -0.288 0.192 _LK(gl)STCIYGGAPK_
DDX17 Ubiquitylation K517 -0.580 0.187 _STNK(gl)GTAYTFFTPGNLK_
DDX17 Ubiquitylation K207 -0.829 0.102 _STCIYGGAPK(gl)GPQIR_
DDX17 Ubiquitylation K264 -1.652 _K(gl)IVDQIRPDR_
DDX17 Phosphorylation S66 -1.474 -2.596 _ESAAPAAAPTAEAPPPSVVTRPEPQALPS(ph)PAIR_
DDX17 Phosphorylation T57 -3.266 _ESAAPAAAPTAEAPPPSVVT(ph)RPEPQALPSPAIR_

Background Information for DDX17:


Pubmed-DDX17 »
Uniprot-DDX17 »
Biogrid-DDX17 »
ProteomicsDB-DDX17 »

Tumorportal-DDX17 »
COSMIC-DDX17 »
GenomeRNAi-DDX17 »
Genecards-DDX17


Protein-protein Interactions for DDX17
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC9 Cat. description Hein, Mann, Cell 2015
Category members IP bait FUS Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNPS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DDX17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DDX17
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members RNA_helicase_DEAD_Q_motif IPR014014 0.24


Protein complexes (CORUM database) featuring DDX17
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1332 Large Drosha complex Database 0.08
Category members Corum 3082 DGCR8 multiprotein complex Database 0.07


Categories featuring DDX17
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway Database 0.25
Category members GO Category GO:0006396 RNA processing Database 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0003724 RNA helicase activity Database 0.07
Category members GO Category GO:0008186 RNA-dependent ATPase activity Database 0.07
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0030331 estrogen receptor binding Database 0


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