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Query: CSTF2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CSTF2 0 -1.720 -0.939 -0.663 0.068 -0.442 -0.123

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CSTF2 Ubiquitylation K148 0.429 0.722 _QMK(gl)LCVQNSPQEAR_
CSTF2 Phosphorylation S538 -1.435 _QVPVMQGTGMQGASIQGGS(ph)QPGGFSPGQNQVTPQDHEK_
CSTF2 Ubiquitylation K55 -0.926 _LVYDRETGK(gl)PK_
CSTF2 Ubiquitylation K96 -0.716 _VDNAASEK(gl)NKEELK_
CSTF2 Ubiquitylation K98 -0.716 _VDNAASEK(gl)NKEELK_
CSTF2 Ubiquitylation K592 -0.132 _EQIQK(gl)STGAP_

Background Information for CSTF2:


Pubmed-CSTF2 »
Uniprot-CSTF2 »
Biogrid-CSTF2 »
ProteomicsDB-CSTF2 »

Tumorportal-CSTF2 »
COSMIC-CSTF2 »
GenomeRNAi-CSTF2 »
Genecards-CSTF2


Protein-protein Interactions for CSTF2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CPSF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait FIP1L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21B Cat. description Hein, Mann, Cell 2015
Category members IP bait MKNK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYMPK Cat. description Hein, Mann, Cell 2015
Category members IP bait CPEB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPSF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSTF2T Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CSTF2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34


Protein complexes (CORUM database) featuring CSTF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1146 Cleavage stimulation factor Database 0.08
Category members Corum 2783 BARD1-BRCA1-CSTF64 complex Database 0.06
Category members Corum 1147 Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3) Database 0
Category members Corum 2211 BARD1-BRCA1-CSTF complex Database 0


Categories featuring CSTF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members Pathway Pathway_852 REACTOME_MRNA_3_END_PROCESSING 0 2.02
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_854 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ 0 0.91
Category members GO Category GO:0031124 mRNA 3'-end processing Database 0.91
Category members GO Category GO:0006369 termination of RNA polymerase II transcription Database 0.87
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members Pathway Pathway_855 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS 0 0.29
Category members GO Category GO:0005847 mRNA cleavage and polyadenylation specificity factor complex Database 0.11
Category members GO Category GO:0006378 mRNA polyadenylation Database 0.1
Category members Pathway Pathway_853 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA 0 0.05
Category members GO Category GO:0006379 mRNA cleavage Database 0


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