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Query: COPS5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
COPS5 0 3.473 -0.780 1.480 -0.905 0.882 0.714

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
COPS5 Ubiquitylation K180 0.752 _TISAGK(gl)VNLGAFR_
COPS5 Ubiquitylation K34 0.220 _K(gl)QQQEILAAKPWTK_
COPS5 Ubiquitylation K56 0.550 _YCK(gl)ISALALLK_
COPS5 Ubiquitylation K194 -1.866 _GYK(gl)PPDEGPSEYQTIPLNK_

Background Information for COPS5:


Pubmed-COPS5 »
Uniprot-COPS5 »
Biogrid-COPS5 »
ProteomicsDB-COPS5 »

Tumorportal-COPS5 »
COSMIC-COPS5 »
GenomeRNAi-COPS5 »
Genecards-COPS5


Protein-protein Interactions for COPS5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait COPS7A Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL4B Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DTL Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait APBB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS7B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DENR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DET1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPD52L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2M Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in COPS5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members JAMM/MPN+_dom IPR000555 1.33


Protein complexes (CORUM database) featuring COPS5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 728 CSA-POLIIa complex Database 1.74
Category members Corum 726 DDB2 complex Database 1.33
Category members Corum 727 CSA complex Database 1.33
Category members Corum 2174 COP9 signalosome complex Database 0.48
Category members Corum 2179 CNS-P53 complex Database 0.19


Categories featuring COPS5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005852 eukaryotic translation initiation factor 3 complex Database 2.27
Category members GO Category GO:0008180 COP9 signalosome Database 1.47
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0010388 cullin deneddylation Database 0.25
Category members GO Category GO:0046328 regulation of JNK cascade Database 0.22
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members Pathway Pathway_407 BIOCARTA_HIF_PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_976 PID_HIF1A_PATHWAY 0 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0008237 metallopeptidase activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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