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Query: COMT

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
COMT 1 5.949 -2.310 4.960 0.523 0.939

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
COMT Ubiquitylation K159 -0.475 0.002 _MVDFAGVK(gl)DK_
COMT Ubiquitylation K161 -0.475 0.002 _MVDFAGVK(gl)DK_

Background Information for COMT:


Pubmed-COMT »
Uniprot-COMT »
Biogrid-COMT »
ProteomicsDB-COMT »

Tumorportal-COMT »
COSMIC-COMT »
GenomeRNAi-COMT »
Genecards-COMT


Protein-protein Interactions for COMT
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait COMT Cat. description Hein, Mann, Cell 2015


Protein Domains in COMT
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAM-dependent_MTases-like IPR029063 0.04
Category members O-MeTrfase_3 IPR002935 0.04


Protein complexes (CORUM database) featuring COMT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring COMT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Disease phenotype 22q11.2_Deletion_Syndrome 22q11.2 Deletion Syndrome Database 0.31
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0007565 female pregnancy Database 0.19
Category members GO Category GO:0008210 estrogen metabolic process Database 0.07
Category members GO Category GO:0048609 multicellular organismal reproductive process Database 0.03
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_154 KEGG_TYROSINE_METABOLISM 0 0
Category members Pathway Pathway_82 REACTOME_PHASE_II_CONJUGATION 0 0
Category members Pathway Pathway_85 REACTOME_BIOLOGICAL_OXIDATIONS 0 0
Category members Pathway Pathway_89 KEGG_STEROID_HORMONE_BIOSYNTHESIS 0 0
Category members Disease phenotype ALCOHOL_DEPENDENCE ALCOHOL DEPENDENCE Database 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0006584 catecholamine metabolic process Database 0
Category members GO Category GO:0006805 xenobiotic metabolic process Database 0
Category members GO Category GO:0007612 learning Database 0
Category members GO Category GO:0008171 O-methyltransferase activity Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0016206 catechol O-methyltransferase activity Database 0
Category members GO Category GO:0032259 methylation Database 0
Category members GO Category GO:0042135 neurotransmitter catabolic process Database 0
Category members GO Category GO:0042136 neurotransmitter biosynthetic process Database 0
Category members GO Category GO:0042417 dopamine metabolic process Database 0
Category members GO Category GO:0042420 dopamine catabolic process Database 0
Category members GO Category GO:0045963 negative regulation of dopamine metabolic process Database 0
Category members GO Category GO:0048265 response to pain Database 0
Category members GO Category GO:0048662 negative regulation of smooth muscle cell proliferation Database 0


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