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Query: CLP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CLP1 1 0.619 1.560 -1.130 -2.044 -4.197

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CLP1 Ubiquitylation K138 1.918 0.745 _VMVVGPTDVGK(gl)STVCR_
CLP1 Ubiquitylation K292 0.258 0.199 _TVLLPK(gl)SGGVVER_

Background Information for CLP1:


Pubmed-CLP1 »
Uniprot-CLP1 »
Biogrid-CLP1 »
ProteomicsDB-CLP1 »

Tumorportal-CLP1 »
COSMIC-CLP1 »
GenomeRNAi-CLP1 »
Genecards-CLP1


Protein-protein Interactions for CLP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait AMMECR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBLAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSEN15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSEN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CLP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members MobB-typ_P-loop IPR029007 0.21
Category members Pre-mRNA_cleavage_cplxII_Clp1 IPR010655 0.05


Protein complexes (CORUM database) featuring CLP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1141 CF IIAm complex (Cleavage factor IIAm complex) Database 2.57
Category members Corum 5283 tRNA splicing endonuclease Database 0.17
Category members Corum 5284 RNA endonuclease (SEN2deltaEx8, SEN54, CLP1) Database 0


Categories featuring CLP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members Pathway Pathway_852 REACTOME_MRNA_3_END_PROCESSING 0 2.02
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_854 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ 0 0.91
Category members GO Category GO:0031124 mRNA 3'-end processing Database 0.91
Category members GO Category GO:0006369 termination of RNA polymerase II transcription Database 0.87
Category members Pathway Pathway_855 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS 0 0.29
Category members GO Category GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation Database 0.22
Category members GO Category GO:0005849 mRNA cleavage factor complex Database 0.13
Category members Pathway Pathway_853 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA 0 0.05
Category members GO Category GO:0000214 tRNA-intron endonuclease complex Database 0
Category members GO Category GO:0030423 targeting of mRNA for destruction involved in RNA interference Database 0
Category members GO Category GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity Database 0


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