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Query: CDK12

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDK12 0 0.516 1.020 -0.690 -0.510 0.013

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDK12 Phosphorylation S385 0.649 _HSSIS(ph)PVRLPLNSSLGAELSR_
CDK12 Phosphorylation T514 0.364 0.570 _DSKPIALKEEIVT(ph)PK_
CDK12 Phosphorylation S236 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK12 Phosphorylation S249 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK12 Phosphorylation S420 0.004 -0.202 _ES(ph)KGSPVFLPR_
CDK12 Phosphorylation S423 -0.155 -0.297 _GS(ph)PVFLPR_
CDK12 Phosphorylation T1244 -0.956 _RT(ph)PTMPQEEAAACPPHILPPEK_
CDK12 Phosphorylation S1082 -1.661 -0.980 _KETTSGTSTEPVKNS(ph)SPAPPQPAPGK_
CDK12 Phosphorylation S1083 -1.093 -1.330 _NSS(ph)PAPPQPAPGK_
CDK12 Phosphorylation T692 -0.765 -1.849 _AIT(ph)PPQQPYK_
CDK12 Phosphorylation S681 -2.532 -2.051 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK12 Phosphorylation S685 -2.729 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_

Background Information for CDK12:


Pubmed-CDK12 »
Uniprot-CDK12 »
Biogrid-CDK12 »
ProteomicsDB-CDK12 »

Tumorportal-CDK12 »
COSMIC-CDK12 »
GenomeRNAi-CDK12 »
Genecards-CDK12


Protein-protein Interactions for CDK12
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCLAF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2B Cat. description Hein, Mann, Cell 2015
Category members IP bait RNPS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL37A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPS14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDK12
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CDK12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3


Categories featuring CDK12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity Database 0.42
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0004693 cyclin-dependent protein serine/threonine kinase activity Database 0.08
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0002944 cyclin K-CDK12 complex Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex Database 0
Category members GO Category GO:0030332 cyclin binding Database 0
Category members GO Category GO:0043405 regulation of MAP kinase activity Database 0


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