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Query: CDC20

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDC20 0 -4.233 0.030 0.220 -0.353 -1.700

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDC20 Ubiquitylation K149 -1.522 -0.046 _LK(gl)VLYSQK_
CDC20 Ubiquitylation K490 -0.793 -0.202 _ASAAK(gl)SSLIHQGIR_
CDC20 Ubiquitylation K136 -1.643 -0.774 _LSGK(gl)PQNAPEGYQNR_
CDC20 Phosphorylation T70 -0.739 -0.822 _VQTT(ph)PSKPGGDR_
CDC20 Ubiquitylation K155 -1.662 -1.144 _VLYSQK(gl)ATPGSSR_
CDC20 Phosphorylation S41 -2.364 _EAAGPAPS(ph)PMR_

Background Information for CDC20:


Pubmed-CDC20 »
Uniprot-CDC20 »
Biogrid-CDC20 »
ProteomicsDB-CDC20 »

Tumorportal-CDC20 »
COSMIC-CDC20 »
GenomeRNAi-CDC20 »
Genecards-CDC20


Protein-protein Interactions for CDC20
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC15 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1B Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC20 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait HAUS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HUWE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHAC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSSCA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDC20
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52


Protein complexes (CORUM database) featuring CDC20
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 190 Mitotic checkpoint complex (MCC) Database 0
Category members Corum 2718 MAD2-CDC20 complex Database 0


Categories featuring CDC20
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.38
Category members GO Category GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.35
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members Pathway Pathway_780 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 0 2.46
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members Pathway Pathway_784 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 0 2.26
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members Pathway Pathway_836 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A 0 1.58
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_818 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B 0 1.37
Category members Pathway Pathway_811 REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 0 1.14
Category members Pathway Pathway_1247 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE 0 1.09
Category members Pathway Pathway_1246 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS 0 0.98
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0007094 mitotic spindle assembly checkpoint Database 0.68
Category members GO Category GO:0005680 anaphase-promoting complex Database 0.63
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members GO Category GO:0050773 regulation of dendrite development Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0031915 positive regulation of synaptic plasticity Database 0
Category members GO Category GO:0040020 regulation of meiosis Database 0
Category members GO Category GO:0051488 activation of anaphase-promoting complex activity Database 0


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