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Query: CD2AP

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CD2AP 0 -0.558 -0.900 -0.330 1.125 -0.237 -0.281 -1.465 -1.354

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CD2AP Phosphorylation T512 0.845 _FNGGHS(ph)PTHSPEK_
CD2AP Phosphorylation S510 0.349 0.536 _FNGGHS(ph)PTHSPEK_
CD2AP Ubiquitylation K71 -0.241 0.187 _ETEFKDDSLPIK(gl)R_
CD2AP Ubiquitylation K226 0.603 _EGSVK(gl)LR_

Background Information for CD2AP:


Pubmed-CD2AP »
Uniprot-CD2AP »
Biogrid-CD2AP »
ProteomicsDB-CD2AP »

Tumorportal-CD2AP »
COSMIC-CD2AP »
GenomeRNAi-CD2AP »
Genecards-CD2AP


Protein-protein Interactions for CD2AP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP6AP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD2AP Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP55 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF15 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF23 Cat. description Hein, Mann, Cell 2015
Category members IP bait RACGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPAST Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGAP44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAPZA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DACH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RACGAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SETX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH3KBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAS2R7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCP10L Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CD2AP
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH3_domain IPR001452 0


Protein complexes (CORUM database) featuring CD2AP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 846 RICH1/AMOT polarity complex, Flag-Rich1 precipitated Database 0


Categories featuring CD2AP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031252 cell leading edge Database 2.52
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0016050 vesicle organization Database 0.31
Category members GO Category GO:0045296 cadherin binding Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members Pathway Pathway_555 PID_NEPHRIN_NEPH1_PATHWAY 0 0.17
Category members GO Category GO:0031941 filamentous actin Database 0.01
Category members Pathway Pathway_431 PID_VEGFR1_PATHWAY 0 0
Category members Disease phenotype Familial_idiopathic_steroid-resistant_nephrotic_syndrome_with_focal_segmental_hyalinosis Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis Database 0
Category members GO Category GO:0005172 vascular endothelial growth factor receptor binding Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0006930 substrate-dependent cell migration, cell extension Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0030139 endocytic vesicle Database 0


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