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Query: CCT8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CCT8 0 -0.529 0.440 0.010 -0.129 -0.611 -0.510 0.526 0.536

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CCT8 Ubiquitylation K171 1.213 _TSIMSK(gl)QYGNEVFLAK_
CCT8 Ubiquitylation K318 -0.421 1.097 _LNSK(gl)WDLRR_
CCT8 Ubiquitylation K235 0.538 1.082 _ETEGDVTSVK(gl)DAK_
CCT8 Ubiquitylation K400 0.364 0.867 _AVDDGVNTFK(gl)VLTR_
CCT8 Ubiquitylation K37 0.439 0.860 _NIQACK(gl)ELAQTTR_
CCT8 Ubiquitylation K238 0.548 _ETEGDVTSVK(gl)DAK_
CCT8 Ubiquitylation K20 0.278 0.511 _EGAK(gl)HFSGLEEAVYR_
CCT8 Ubiquitylation K326 0.065 0.098 _RLCK(gl)TVGATALPR_
CCT8 Ubiquitylation K459 -0.052 0.061 _ALAENSGVK(gl)ANEVISK_
CCT8 Ubiquitylation K16 -0.003 -0.077 _APGFAQM(ox)LK(gl)EGAK_
CCT8 Ubiquitylation K7 -0.282 -0.604 _(ac)ALHVPK(gl)APGFAQMLK_
CCT8 Phosphorylation S537 -1.069 -1.022 _PAGGPKPPS(ph)GK_
CCT8 Ubiquitylation K152 -0.270 _AHEILPNLVCCSAK(gl)NLR_
CCT8 Ubiquitylation K260 0.152 _GTVLIK(gl)TAEELMNFSK_
CCT8 Ubiquitylation K270 0.187 _TAEELMNFSK(gl)GEENLMDAQVK_
CCT8 Ubiquitylation K440 -0.342 _K(gl)FAEAFEAIPR_
CCT8 Ubiquitylation K466 0.068 _ANEVISK(gl)LYAVHQEGNK_
CCT8 Ubiquitylation K528 -1.602 _VDQIIMAK(gl)PAGGPKPPSGK_
CCT8 Ubiquitylation K534 -2.257 _VDQIIMAKPAGGPK(gl)PPSGK_
CCT8 Ubiquitylation K540 -1.770 _PAGGPKPPSGKK(gl)_

Background Information for CCT8:


Pubmed-CCT8 »
Uniprot-CCT8 »
Biogrid-CCT8 »
ProteomicsDB-CCT8 »

Tumorportal-CCT8 »
COSMIC-CCT8 »
GenomeRNAi-CCT8 »
Genecards-CCT8


Protein-protein Interactions for CCT8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTR1B Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTR2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT4 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT7 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC20 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DTL Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3I Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GBA Cat. description Hein, Mann, Cell 2015
Category members IP bait GNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IGBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ILK Cat. description Hein, Mann, Cell 2015
Category members IP bait JAK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21A Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NIPSNAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NSMAF Cat. description Hein, Mann, Cell 2015
Category members IP bait PDK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PFDN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP6C Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait RFWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMM50 Cat. description Hein, Mann, Cell 2015
Category members IP bait SESN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA3C;TUBA3E Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR48 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR61 Cat. description Hein, Mann, Cell 2015
Category members IP bait WRAP53 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTBL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ACTR3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BUB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXW4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KDM4B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC8A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PEX7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POC1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CCT8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cpn60/TCP-1 IPR002423 0.09
Category members GroEL-like_apical_dom IPR027409 0.09
Category members Chaperone_TCP-1 IPR017998 0.07


Protein complexes (CORUM database) featuring CCT8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 126 CCT micro-complex Database 0.06


Categories featuring CCT8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005874 microtubule Database 1.21
Category members Pathway Pathway_742 REACTOME_PROTEIN_FOLDING 0 0.9
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0051084 'de novo' posttranslational protein folding Database 0.63
Category members Pathway Pathway_1288 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC 0 0.4
Category members Pathway Pathway_741 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS 0 0.29
Category members GO Category GO:0045111 intermediate filament cytoskeleton Database 0.26
Category members Pathway Pathway_1296 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC 0 0.08
Category members GO Category GO:0002199 zona pellucida receptor complex Database 0.07
Category members GO Category GO:0005832 chaperonin-containing T-complex Database 0.06
Category members GO Category GO:0007339 binding of sperm to zona pellucida Database 0
Category members GO Category GO:0016235 aggresome Database 0
Category members GO Category GO:0042623 ATPase activity, coupled Database 0
Category members GO Category GO:0044297 cell body Database 0


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