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Query: CCT2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CCT2 1 5.617 -1.960 4.690 -0.103 -0.462 -0.504 0.251 0.451

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CCT2 Ubiquitylation K154 0.317 0.803 _EALLSSAVDHGSDEVK(gl)FR_
CCT2 Ubiquitylation K46 0.429 _STLGPK(gl)GMDK_
CCT2 Ubiquitylation K82 -0.230 0.384 _NIGVDNPAAK(gl)VLVDMSR_
CCT2 Ubiquitylation K248 0.491 0.333 _ILIANTGMDTDK(gl)IK_
CCT2 Ubiquitylation K120 0.281 0.305 _EAESLIAKK(gl)_
CCT2 Ubiquitylation K522 0.245 0.094 _VDNIIK(gl)AAPR_
CCT2 Ubiquitylation K441 0.095 -0.071 _EAVAM(ox)ESYAK(gl)ALR_
CCT2 Ubiquitylation K13 -0.609 _(ac)ASLSLAPVNIFK(gl)AGADEERAETAR_
CCT2 Ubiquitylation K50 -0.136 _GMDK(gl)ILLSSGR_
CCT2 Ubiquitylation K284 0.170 _ILK(gl)HGINCFINR_
CCT2 Ubiquitylation K431 -0.401 _TPGK(gl)EAVAMESYAK_

Background Information for CCT2:


Pubmed-CCT2 »
Uniprot-CCT2 »
Biogrid-CCT2 »
ProteomicsDB-CCT2 »

Tumorportal-CCT2 »
COSMIC-CCT2 »
GenomeRNAi-CCT2 »
Genecards-CCT2


Protein-protein Interactions for CCT2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTR1B Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTR2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT4 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT7 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC20 Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DTL Cat. description Hein, Mann, Cell 2015
Category members IP bait GNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IGBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21A Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21B Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NIPSNAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NSMAF Cat. description Hein, Mann, Cell 2015
Category members IP bait PDK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PLK4 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP6C Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait RFWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMM50 Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA3C;TUBA3E Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR48 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR61 Cat. description Hein, Mann, Cell 2015
Category members IP bait WRAP53 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTBL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ACTL6A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ACTR1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ACTR3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ACTR3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ANGPTL7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP6V1B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BUB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK11A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXW4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FYCO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GANAB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HCFC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HDAC11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KDM4B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC8A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LCMT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPK10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPK15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLST8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ODF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PEX7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNPLA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNPLA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POC1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POC1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAP2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFWD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SEC31B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMOX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STRADB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBL1Y Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THBS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THOC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRMT12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTLL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTLL9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBA1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBA3C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBA3E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBAL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBB2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBB2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNDC9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR37 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR5B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR77 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR86 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDTC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CCT2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Chaprnin_Cpn60 IPR001844 0.33
Category members Cpn60/TCP-1 IPR002423 0.09
Category members GroEL-like_apical_dom IPR027409 0.09
Category members Chaperone_TCP-1 IPR017998 0.07


Protein complexes (CORUM database) featuring CCT2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 126 CCT micro-complex Database 0.06


Categories featuring CCT2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005874 microtubule Database 1.21
Category members Pathway Pathway_742 REACTOME_PROTEIN_FOLDING 0 0.9
Category members GO Category GO:0051084 'de novo' posttranslational protein folding Database 0.63
Category members Pathway Pathway_1288 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC 0 0.4
Category members Pathway Pathway_741 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS 0 0.29
Category members GO Category GO:0051131 chaperone-mediated protein complex assembly Database 0.24
Category members Pathway Pathway_1296 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC 0 0.08
Category members GO Category GO:0002199 zona pellucida receptor complex Database 0.07
Category members GO Category GO:0005832 chaperonin-containing T-complex Database 0.06
Category members GO Category GO:0007339 binding of sperm to zona pellucida Database 0
Category members GO Category GO:0044297 cell body Database 0


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