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bioLOGIC Data

Query: CBX3

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
CBX3	0	1.553	0.390	0.010	-0.267	-0.513	0.225

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
CBX3	Ubiquitylation	K5	0.311	0.641	_(ac)ASNK(gl)TTLQK_
CBX3	Phosphorylation	S93	0.091	0.587	_RKS(ph)LSDSESDDSK_
CBX3	Ubiquitylation	K154	0.457	-0.090	_WKDSDEADLVLAK(gl)EANMK_
CBX3	Ubiquitylation	K44	0.789		_VVNGK(gl)VEYFLK_
CBX3	Ubiquitylation	K143	0.274		_WK(gl)DSDEADLVLAK_

Background Information for CBX3:

Pubmed-CBX3 »

Uniprot-CBX3 »

Biogrid-CBX3 »

ProteomicsDB-CBX3 »

Tumorportal-CBX3 »

COSMIC-CBX3 »

GenomeRNAi-CBX3 »

Genecards-CBX3

Protein-protein Interactions for CBX3

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait CBX1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait CHAMP1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait MAD2L2	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait MIS12	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait NLRP3	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait TTLL12	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait PCGF6	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in CBX3

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	Chromo_domain/shadow	IPR000953	2.84
Category members	Chromodomain-like	IPR016197	2.29
Category members	Chromo_domain	IPR023780	1.98
Category members	Chromo_dom_subgr	IPR017984	0.83
Category members	Chromo_shadow_dom	IPR008251	0.46

Protein complexes (CORUM database) featuring CBX3

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	929	CEN complex	Database	3.25

Categories featuring CBX3

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	Pathway	Pathway_348	REACTOME_TRANSCRIPTION	0	9
Category members	Pathway	Pathway_351	REACTOME_RNA_POL_I_TRANSCRIPTION	0	8.31
Category members	Pathway	Pathway_350	REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION	0	7.97
Category members	GO Category	GO:0005635	nuclear envelope	Database	7.22
Category members	GO Category	GO:0006338	chromatin remodeling	Database	4.95
Category members	DDR Literature	pubmedid:19647519	Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation		3.6
Category members	GO Category	GO:0000785	chromatin	Database	2.59
Category members	GO Category	GO:0005637	nuclear inner membrane	Database	1.98
Category members	GO Category	GO:0019904	protein domain specific binding	Database	1.85
Category members	GO Category	GO:0019899	enzyme binding	Database	1.57
Category members	GO Category	GO:0005720	nuclear heterochromatin	Database	1.41
Category members	GO Category	GO:0045892	negative regulation of transcription, DNA-dependent	Database	1.15
Category members	GO Category	GO:0006351	transcription, DNA-templated	Database	1.07
Category members	GO Category	GO:0005819	spindle	Database	0.41
Category members	GO Category	GO:0042802	identical protein binding	Database	0.26
Category members	GO Category	GO:0005719	nuclear euchromatin	Database	0.15
Category members	GO Category	GO:0000779	condensed chromosome, centromeric region	Database	0
Category members	GO Category	GO:0031618	nuclear centromeric heterochromatin	Database	0