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Query: BUB1B

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BUB1B 1 4.485 -1.750 3.130

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BUB1B Phosphorylation S670 0.830 0.911 _LS(ph)PIIEDSR_
BUB1B Phosphorylation S543 -0.522 -0.173 _NKS(ph)PPADPPR_
BUB1B Ubiquitylation K438 -0.825 _EAELLTSAEK(gl)R_
BUB1B Ubiquitylation K475 -0.386 _TGDQQEETMPTK(gl)ETTK_

Background Information for BUB1B:


Pubmed-BUB1B »
Uniprot-BUB1B »
Biogrid-BUB1B »
ProteomicsDB-BUB1B »

Tumorportal-BUB1B »
COSMIC-BUB1B »
GenomeRNAi-BUB1B »
Genecards-BUB1B


Protein-protein Interactions for BUB1B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1B Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD14 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC20 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait CERK Cat. description Hein, Mann, Cell 2015
Category members IP bait IMMT Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BUB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TYW3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BUB1B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Mad3_BUB1_I IPR013212 0


Protein complexes (CORUM database) featuring BUB1B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 190 Mitotic checkpoint complex (MCC) Database 0


Categories featuring BUB1B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.35
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members Pathway Pathway_784 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 0 2.26
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_836 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A 0 1.58
Category members GO Category GO:0007091 metaphase/anaphase transition of mitotic cell cycle Database 1.58
Category members Pathway Pathway_1246 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS 0 0.98
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0007094 mitotic spindle assembly checkpoint Database 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0005680 anaphase-promoting complex Database 0.63
Category members GO Category GO:0005815 microtubule organizing center Database 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0000777 condensed chromosome kinetochore Database 0.32
Category members GO Category GO:0007093 mitotic cell cycle checkpoint Database 0.27
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0000940 condensed chromosome outer kinetochore Database 0.18
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members GO Category GO:0000778 condensed nuclear chromosome kinetochore Database 0.11
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0007051 spindle organization Database 0.04
Category members Disease phenotype Mosaic_variegated_aneuploidy_syndrome Mosaic variegated aneuploidy syndrome Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0034501 protein localization to kinetochore Database 0
Category members GO Category GO:0051233 spindle midzone Database 0


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