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Query: BCOR

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BCOR 0 0.914 -0.620 1.340 0.006 -0.709 0.270 -1.186 -0.601

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BCOR Ubiquitylation K530 1.176 _SMSLKNK(gl)_
BCOR Ubiquitylation K1460 0.227 0.495 _RLIVNK(gl)NAGETLLQR_
BCOR Phosphorylation T1129 0.299 _QPVSEPPADQVASDMPHS(ph)PTLR_
BCOR Phosphorylation T1148 -0.101 0.000 _RKVSGDSSHTETT(ph)AEEVPEDPLLK_
BCOR Phosphorylation S422 -0.216 -0.108 _KDGS(ph)SPPLLEK_
BCOR Phosphorylation S1139 -0.208 -0.116 _KVS(ph)GDSSHTETTAEEVPEDPLLK_
BCOR Phosphorylation S423 -0.363 -0.255 _DGSS(ph)PPLLEK_
BCOR Phosphorylation S1290 -0.318 _SWSEESLKPSDNEQGLPVFSGS(ph)PPMK_
BCOR Phosphorylation S1410 -0.698 _KRPEPSSDYDLS(ph)PAK_
BCOR Ubiquitylation K40 -0.709 _ILVNDGDASK(gl)AR_
BCOR Phosphorylation S1127 -1.150 _QPVSEPPADQVASDMPHS(ph)PTLR_
BCOR Phosphorylation S1142 0.092 _RKVSGDS(ph)SHTETTAEEVPEDPLLK_

Background Information for BCOR:


Pubmed-BCOR »
Uniprot-BCOR »
Biogrid-BCOR »
ProteomicsDB-BCOR »

Tumorportal-BCOR »
COSMIC-BCOR »
GenomeRNAi-BCOR »
Genecards-BCOR


Protein-protein Interactions for BCOR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCOR Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX7 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP152 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC11 Cat. description Hein, Mann, Cell 2015
Category members IP bait GSK3B Cat. description Hein, Mann, Cell 2015
Category members IP bait HMG20A Cat. description Hein, Mann, Cell 2015
Category members IP bait IPO8 Cat. description Hein, Mann, Cell 2015
Category members IP bait MLLT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCGF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PTPN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RING1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNASEH2B Cat. description Hein, Mann, Cell 2015
Category members IP bait RNF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SGOL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait USP7 Cat. description Hein, Mann, Cell 2015
Category members IP bait C6orf141 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CARD8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CBX7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSN1S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ERP44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait L3MBTL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCAPH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRR20E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QPRT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RYBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BCOR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ankyrin_rpt IPR002110 0
Category members Ankyrin_rpt-contain_dom IPR020683 0


Protein complexes (CORUM database) featuring BCOR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1178 BCOR complex Database 0.34


Categories featuring BCOR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0031072 heat shock protein binding Database 1.59
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0031519 PcG protein complex Database 0.62
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0035518 histone H2A monoubiquitination Database 0.34
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0042476 odontogenesis Database 0.09
Category members GO Category GO:0051572 negative regulation of histone H3-K4 methylation Database 0.08
Category members GO Category GO:0030502 negative regulation of bone mineralization Database 0.05
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0065001 specification of axis polarity Database 0


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