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Query: BCL11A

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BCL11A 0 2.219 0.570 -0.910 -0.307
BCL11A 0 2.219 0.570 -0.910 0.205 0.251

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BCL11A Phosphorylation T701 0.381 0.980 _FST(ph)PPGELDGGISGR_
BCL11A Phosphorylation S447 0.783 0.547 _SDDGLSTASS(ph)PEPGTSDLVGSASSALK_
BCL11A Phosphorylation S608 0.412 0.400 _GCS(ph)PGESASGGLSK_
BCL11A Phosphorylation S718 0.367 _SGTGS(ph)GGSTPHISGPGPGRPSSK_
BCL11A Phosphorylation S625 0.458 0.304 _LLLGS(ph)PSSLSPFSK_
BCL11A Phosphorylation S205 -0.387 0.246 _IYLESEHGS(ph)PLTPR_
BCL11A Phosphorylation S88 -0.768 -0.180 _AVDKPPSPS(ph)PIEM(ox)K_
BCL11A Phosphorylation S86 -0.529 -0.504 _AVDKPPS(ph)PSPIEMK_
BCL11A Phosphorylation S630 -0.946 -1.128 _LLLGSPSSLS(ph)PFSK_
BCL11A Phosphorylation S328 -2.457 -1.626 _ELAGNTSS(ph)PPLSPGRPSPMQR_

Background Information for BCL11A:


Pubmed-BCL11A »
Uniprot-BCL11A »
Biogrid-BCL11A »
ProteomicsDB-BCL11A »

Tumorportal-BCL11A »
COSMIC-BCL11A »
GenomeRNAi-BCL11A »
Genecards-BCL11A


Protein-protein Interactions for BCL11A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FGFR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBD3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHF20L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBXN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BCL11A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92


Protein complexes (CORUM database) featuring BCL11A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring BCL11A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0016925 protein sumoylation Database 0.33
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0032463 negative regulation of protein homooligomerization Database 0.11
Category members GO Category GO:0050773 regulation of dendrite development Database 0.08
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members GO Category GO:0010977 negative regulation of neuron projection development Database 0.04
Category members Disease phenotype Hereditary_persistence_of_fetal_hemoglobin_-_beta-thalassemia Hereditary persistence of fetal hemoglobin - beta-thalassemia Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0030217 T cell differentiation Database 0
Category members GO Category GO:0030517 negative regulation of axon extension Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048671 negative regulation of collateral sprouting Database 0
Category members GO Category GO:0048672 positive regulation of collateral sprouting Database 0


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