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Query: ATP2A1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ATP2A1 2 12.929 -1.020 1.690 0.192 -0.474 0.081 0.297

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ATP2A1 Ubiquitylation K611 5.174 4.269 _IEVASSVK(gl)LCR_
ATP2A1 Ubiquitylation K543 1.447 3.874 _QK(gl)IMSVIR_
ATP2A1 Ubiquitylation K757 2.081 3.431 _AIYNNMK(gl)QFIR_
ATP2A1 Ubiquitylation K476 1.817 3.302 _ANACNSVIK(gl)QLMK_
ATP2A1 Ubiquitylation K169 2.444 3.235 _LTSIK(gl)STTLR_
ATP2A1 Ubiquitylation K464 1.160 3.034 _GLSK(gl)IER_
ATP2A1 Ubiquitylation K541 2.787 _VPMTSGVK(gl)QK_
ATP2A1 Ubiquitylation K533 1.659 2.743 _VGSTK(gl)VPMTSGVK_
ATP2A1 Ubiquitylation K628 0.545 2.714 _VIMITGDNK(gl)GTAVAICR_
ATP2A1 Ubiquitylation K436 2.681 _GVYEK(gl)VGEATETALTCLVEK_
ATP2A1 Ubiquitylation K650 1.861 2.614 _IGIFGQDEDVTSK(gl)AFTGR_
ATP2A1 Ubiquitylation K510 1.498 2.485 _TSMSK(gl)MFVK_
ATP2A1 Ubiquitylation K514 1.598 2.466 _MFVK(gl)GAPEGVIDR_
ATP2A1 Ubiquitylation K460 0.597 2.302 _MNVFDTELK(gl)GLSK_
ATP2A1 Ubiquitylation K712 2.111 _K(gl)AEIGIAMGSGTAVAK_
ATP2A1 Ubiquitylation K480 2.106 _ANACNSVIKQLMK(gl)_
ATP2A1 Ubiquitylation K995 -1.164 1.549 _NYLEPGK(gl)ECVQPATK_
ATP2A1 Ubiquitylation K502 -0.998 1.220 _SMSVYCTPNK(gl)PSR_
ATP2A1 Phosphorylation S663 0.605 0.621 _EFDELNPS(ph)AQR_
ATP2A1 Ubiquitylation K492 0.229 _K(gl)SMSVYCTPNKPSR_

Background Information for ATP2A1:


Pubmed-ATP2A1 »
Uniprot-ATP2A1 »
Biogrid-ATP2A1 »
ProteomicsDB-ATP2A1 »

Tumorportal-ATP2A1 »
COSMIC-ATP2A1 »
GenomeRNAi-ATP2A1 »
Genecards-ATP2A1


Protein-protein Interactions for ATP2A1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GCNT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRTP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HMGB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRCC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ROGDI Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SETDB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VNN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ATP2A1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ATPase_P-typ_cation-transptr_N IPR004014 0.18
Category members ATPase_P-typ_cation-transptr_C IPR006068 0.18
Category members ATPase_P-typ_cyto_domN IPR023299 0.18
Category members ATPase_P-typ_Ca-transp_IIA IPR005782 0.13
Category members Cation_transp_P_typ_ATPase IPR001757 0.08
Category members ATPase_P-typ_transduc_dom_A IPR008250 0.08
Category members HAD-like_dom IPR023214 0


Protein complexes (CORUM database) featuring ATP2A1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ATP2A1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005388 calcium-transporting ATPase activity Database 1.06
Category members GO Category GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Database 0.91
Category members GO Category GO:0005793 endoplasmic reticulum-Golgi intermediate compartment Database 0.74
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0031095 platelet dense tubular network membrane Database 0.45
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0031673 H zone Database 0.32
Category members Pathway Pathway_1188 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS 0 0.32
Category members GO Category GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration Database 0.3
Category members GO Category GO:0034704 calcium channel complex Database 0.21
Category members GO Category GO:0006942 regulation of striated muscle contraction Database 0.17
Category members GO Category GO:0019829 cation-transporting ATPase activity Database 0.15
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members Pathway Pathway_113 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 0 0.08
Category members Pathway Pathway_285 REACTOME_PLATELET_HOMEOSTASIS 0 0.08
Category members GO Category GO:0051659 maintenance of mitochondrion location Database 0.08
Category members GO Category GO:0034976 response to endoplasmic reticulum stress Database 0.06
Category members GO Category GO:0045988 negative regulation of striated muscle contraction Database 0.04
Category members GO Category GO:0008637 apoptotic mitochondrial changes Database 0.01
Category members Pathway Pathway_108 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI 0 0
Category members Pathway Pathway_182 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES 0 0
Category members Pathway Pathway_183 REACTOME_ION_CHANNEL_TRANSPORT 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members GO Category GO:0006812 cation transport Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0016529 sarcoplasmic reticulum Database 0
Category members GO Category GO:0031674 I band Database 0
Category members GO Category GO:0033017 sarcoplasmic reticulum membrane Database 0
Category members GO Category GO:0034220 ion transmembrane transport Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051561 positive regulation of mitochondrial calcium ion concentration Database 0
Category members GO Category GO:0070509 calcium ion import Database 0


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