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Query: ATP1A2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ATP1A2 0 2.356 0.000 0.440 0.377 0.914 -1.883 0.083 0.031

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ATP1A2 Ubiquitylation K476 1.195 _YAK(gl)IVEIPFNSTNK_
ATP1A2 Ubiquitylation K36 1.089 0.875 _DMDELK(gl)K_
ATP1A2 Ubiquitylation K156 -1.024 0.552 _SSK(gl)IMESFK_
ATP1A2 Ubiquitylation K468 -0.291 0.462 _CIELCCGSVK(gl)EMR_
ATP1A2 Ubiquitylation K952 -1.917 0.295 _NSVFQQGMKNK(gl)_
ATP1A2 Ubiquitylation K9 0.245 0.226 _DK(gl)YEPAAVSEQGDKK_
ATP1A2 Ubiquitylation K162 -0.474 0.225 _IMESFK(gl)NMVPQQALVIR_
ATP1A2 Ubiquitylation K54 -1.233 0.206 _K(gl)YGTDLSR_
ATP1A2 Ubiquitylation K605 0.393 0.204 _AAVPDAVGK(gl)CR_
ATP1A2 Ubiquitylation K629 0.204 _AIAK(gl)GVGIISEGNETVEDIAAR_
ATP1A2 Ubiquitylation K773 0.165 _LIFDNLK(gl)K_
ATP1A2 Ubiquitylation K843 0.143 _TDK(gl)LVNER_
ATP1A2 Phosphorylation S16 -0.121 0.100 _DKYEPAAVS(ph)EQGDKK_
ATP1A2 Ubiquitylation K950 0.029 _NSVFQQGMK(gl)NK_
ATP1A2 Ubiquitylation K661 -1.060 -0.037 _DAK(gl)ACVVHGSDLK_
ATP1A2 Ubiquitylation K377 -1.676 -0.190 _NLEAVETLGSTSTICSDK(gl)TGTLTQNR_
ATP1A2 Ubiquitylation K212 -0.693 -0.230 _IISANGCK(gl)VDNSSLTGESEPQTR_
ATP1A2 Ubiquitylation K444 -0.592 -0.292 _AVFQANQENLPILK(gl)R_
ATP1A2 Ubiquitylation K726 -1.405 -0.328 _QGAIVAVTGDGVNDSPALK(gl)K_
ATP1A2 Ubiquitylation K698 -1.846 -0.336 _TSPQQK(gl)LIIVEGCQR_
ATP1A2 Ubiquitylation K727 -1.257 -0.518 _QGAIVAVTGDGVNDSPALKK(gl)_
ATP1A2 Ubiquitylation K625 -2.291 -0.674 _VIMVTGDHPITAK(gl)AIAK_
ATP1A2 Ubiquitylation K840 -1.467 -0.964 _NPK(gl)TDKLVNER_
ATP1A2 Ubiquitylation K508 -1.151 _NPNTSEPQHLLVMK(gl)GAPER_
ATP1A2 Ubiquitylation K22 0.726 _DKYEPAAVSEQGDKK(gl)_
ATP1A2 Ubiquitylation K24 0.135 _YEPAAVSEQGDKKGK(gl)_
ATP1A2 Ubiquitylation K37 1.220 _DMDELK(gl)KEVSMDDHK_
ATP1A2 Ubiquitylation K45 -0.107 _EVSMDDHK(gl)LSLDELHR_

Background Information for ATP1A2:


Pubmed-ATP1A2 »
Uniprot-ATP1A2 »
Biogrid-ATP1A2 »
ProteomicsDB-ATP1A2 »

Tumorportal-ATP1A2 »
COSMIC-ATP1A2 »
GenomeRNAi-ATP1A2 »
Genecards-ATP1A2


Protein-protein Interactions for ATP1A2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARHGEF16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DOCK5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RY8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ROGDI Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ATP1A2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ATPase_P-typ_cation-transptr_N IPR004014 0.18
Category members ATPase_P-typ_cation-transptr_C IPR006068 0.18
Category members ATPase_P-typ_cyto_domN IPR023299 0.18
Category members Cation_transp_P_typ_ATPase IPR001757 0.08
Category members ATPase_P-typ_transduc_dom_A IPR008250 0.08
Category members ATPase_P-typ_Na/K_IIC IPR005775 0
Category members HAD-like_dom IPR023214 0


Protein complexes (CORUM database) featuring ATP1A2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ATP1A2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members GO Category GO:0042383 sarcolemma Database 0.36
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0006942 regulation of striated muscle contraction Database 0.17
Category members GO Category GO:0019829 cation-transporting ATPase activity Database 0.15
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0006813 potassium ion transport Database 0.11
Category members GO Category GO:0008217 regulation of blood pressure Database 0.09
Category members GO Category GO:0006814 sodium ion transport Database 0.09
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0019229 regulation of vasoconstriction Database 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0045988 negative regulation of striated muscle contraction Database 0.04
Category members Pathway Pathway_176 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0 0
Category members Pathway Pathway_182 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES 0 0
Category members Pathway Pathway_183 REACTOME_ION_CHANNEL_TRANSPORT 0 0
Category members Pathway Pathway_198 KEGG_CARDIAC_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_36 KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION 0 0
Category members Disease phenotype ALTERNATING_HEMIPLEGIA_OF_CHILDHOOD ALTERNATING HEMIPLEGIA OF CHILDHOOD Database 0
Category members Disease phenotype Familial_or_sporadic_hemiplegic_migraine Familial or sporadic hemiplegic migraine Database 0
Category members GO Category GO:0001504 neurotransmitter uptake Database 0
Category members GO Category GO:0002026 regulation of the force of heart contraction Database 0
Category members GO Category GO:0002087 regulation of respiratory gaseous exchange by neurological system process Database 0
Category members GO Category GO:0005391 sodium:potassium-exchanging ATPase activity Database 0
Category members GO Category GO:0005890 sodium:potassium-exchanging ATPase complex Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0006754 ATP biosynthetic process Database 0
Category members GO Category GO:0006812 cation transport Database 0
Category members GO Category GO:0006937 regulation of muscle contraction Database 0
Category members GO Category GO:0006940 regulation of smooth muscle contraction Database 0
Category members GO Category GO:0008344 adult locomotory behavior Database 0
Category members GO Category GO:0008542 visual learning Database 0
Category members GO Category GO:0015077 monovalent inorganic cation transmembrane transporter activity Database 0
Category members GO Category GO:0015672 monovalent inorganic cation transport Database 0
Category members GO Category GO:0015991 ATP hydrolysis coupled proton transport Database 0
Category members GO Category GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Database 0
Category members GO Category GO:0030315 T-tubule Database 0
Category members GO Category GO:0034220 ion transmembrane transport Database 0
Category members GO Category GO:0035094 response to nicotine Database 0
Category members GO Category GO:0040011 locomotion Database 0
Category members GO Category GO:0045822 negative regulation of heart contraction Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051481 negative regulation of cytosolic calcium ion concentration Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0


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