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bioLOGIC Data

Query: ATP1A1

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
ATP1A1	0	1.916	0.410	-0.420	0.377	0.914	-1.883	0.083	0.031

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
ATP1A1	Ubiquitylation	K476		1.195	_YAK(gl)IVEIPFNSTNK_
ATP1A1	Ubiquitylation	K36	1.089	0.875	_DMDELK(gl)K_
ATP1A1	Ubiquitylation	K156	-1.024	0.552	_SSK(gl)IMESFK_
ATP1A1	Ubiquitylation	K468	-0.291	0.462	_CIELCCGSVK(gl)EMR_
ATP1A1	Ubiquitylation	K952	-1.917	0.295	_NSVFQQGMKNK(gl)_
ATP1A1	Ubiquitylation	K9	0.245	0.226	_DK(gl)YEPAAVSEQGDKK_
ATP1A1	Ubiquitylation	K162	-0.474	0.225	_IMESFK(gl)NMVPQQALVIR_
ATP1A1	Ubiquitylation	K54	-1.233	0.206	_K(gl)YGTDLSR_
ATP1A1	Ubiquitylation	K605	0.393	0.204	_AAVPDAVGK(gl)CR_
ATP1A1	Ubiquitylation	K629		0.204	_AIAK(gl)GVGIISEGNETVEDIAAR_
ATP1A1	Ubiquitylation	K773		0.165	_LIFDNLK(gl)K_
ATP1A1	Ubiquitylation	K843		0.143	_TDK(gl)LVNER_
ATP1A1	Phosphorylation	S16	-0.121	0.100	_DKYEPAAVS(ph)EQGDKK_
ATP1A1	Ubiquitylation	K950		0.029	_NSVFQQGMK(gl)NK_
ATP1A1	Ubiquitylation	K661	-1.060	-0.037	_DAK(gl)ACVVHGSDLK_
ATP1A1	Ubiquitylation	K377	-1.676	-0.190	_NLEAVETLGSTSTICSDK(gl)TGTLTQNR_
ATP1A1	Ubiquitylation	K212	-0.693	-0.230	_IISANGCK(gl)VDNSSLTGESEPQTR_
ATP1A1	Ubiquitylation	K444	-0.592	-0.292	_AVFQANQENLPILK(gl)R_
ATP1A1	Ubiquitylation	K726	-1.405	-0.328	_QGAIVAVTGDGVNDSPALK(gl)K_
ATP1A1	Ubiquitylation	K698	-1.846	-0.336	_TSPQQK(gl)LIIVEGCQR_
ATP1A1	Ubiquitylation	K727	-1.257	-0.518	_QGAIVAVTGDGVNDSPALKK(gl)_
ATP1A1	Ubiquitylation	K625	-2.291	-0.674	_VIMVTGDHPITAK(gl)AIAK_
ATP1A1	Ubiquitylation	K840	-1.467	-0.964	_NPK(gl)TDKLVNER_
ATP1A1	Ubiquitylation	K508		-1.151	_NPNTSEPQHLLVMK(gl)GAPER_
ATP1A1	Ubiquitylation	K22	0.726		_DKYEPAAVSEQGDKK(gl)_
ATP1A1	Ubiquitylation	K24	0.135		_YEPAAVSEQGDKKGK(gl)_
ATP1A1	Ubiquitylation	K37	1.220		_DMDELK(gl)KEVSMDDHK_
ATP1A1	Ubiquitylation	K45	-0.107		_EVSMDDHK(gl)LSLDELHR_

Background Information for ATP1A1:

Pubmed-ATP1A1 »

Uniprot-ATP1A1 »

Biogrid-ATP1A1 »

ProteomicsDB-ATP1A1 »

Tumorportal-ATP1A1 »

COSMIC-ATP1A1 »

GenomeRNAi-ATP1A1 »

Genecards-ATP1A1

Protein-protein Interactions for ATP1A1

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait BMPR1A	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait ECM29;KIAA0368	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait ERBB2	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait GOLT1B	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait HNRNPF	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait MBOAT1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait NCSTN	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait TMEM63B	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait TNPO1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait TUBA1C	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait TUBG1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait YIPF5	Cat. description	Hein, Mann, Cell 2015

Protein Domains in ATP1A1

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	ATPase_P-typ_cation-transptr_N	IPR004014	0.18
Category members	ATPase_P-typ_cation-transptr_C	IPR006068	0.18
Category members	ATPase_P-typ_cyto_domN	IPR023299	0.18
Category members	Cation_transp_P_typ_ATPase	IPR001757	0.08
Category members	ATPase_P-typ_transduc_dom_A	IPR008250	0.08
Category members	ATPase_P-typ_Na/K_IIC	IPR005775	0
Category members	HAD-like_dom	IPR023214	0

Protein complexes (CORUM database) featuring ATP1A1

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)

Categories featuring ATP1A1

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0016021	integral to membrane	Database	7.67
Category members	GO Category	GO:0000166	nucleotide binding	Database	5.91
Category members	GO Category	GO:0042470	melanosome	Database	5.59
Category members	GO Category	GO:0005524	ATP binding	Database	5.54
Category members	GO Category	GO:0019904	protein domain specific binding	Database	1.85
Category members	GO Category	GO:0051087	chaperone binding	Database	1.69
Category members	GO Category	GO:0005886	plasma membrane	Database	1.21
Category members	GO Category	GO:0042493	response to drug	Database	0.66
Category members	GO Category	GO:0005783	endoplasmic reticulum	Database	0.62
Category members	GO Category	GO:0016020	membrane	Database	0.52
Category members	GO Category	GO:0019901	protein kinase binding	Database	0.37
Category members	GO Category	GO:0042383	sarcolemma	Database	0.36
Category members	GO Category	GO:0045823	positive regulation of heart contraction	Database	0.32
Category members	GO Category	GO:0005768	endosome	Database	0.29
Category members	GO Category	GO:0005794	Golgi apparatus	Database	0.27
Category members	GO Category	GO:0043531	ADP binding	Database	0.27
Category members	GO Category	GO:0019829	cation-transporting ATPase activity	Database	0.15
Category members	GO Category	GO:0055085	transmembrane transport	Database	0.12
Category members	GO Category	GO:0006813	potassium ion transport	Database	0.11
Category members	GO Category	GO:0045121	membrane raft	Database	0.11
Category members	GO Category	GO:0008217	regulation of blood pressure	Database	0.09
Category members	GO Category	GO:0006814	sodium ion transport	Database	0.09
Category members	Pathway	Pathway_99	REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES	0	0.08
Category members	GO Category	GO:0016323	basolateral plasma membrane	Database	0.04
Category members	Pathway	Pathway_176	KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION	0	0
Category members	Pathway	Pathway_182	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	0	0
Category members	Pathway	Pathway_183	REACTOME_ION_CHANNEL_TRANSPORT	0	0
Category members	Pathway	Pathway_198	KEGG_CARDIAC_MUSCLE_CONTRACTION	0	0
Category members	Pathway	Pathway_36	KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION	0	0
Category members	GO Category	GO:0002026	regulation of the force of heart contraction	Database	0
Category members	GO Category	GO:0002028	regulation of sodium ion transport	Database	0
Category members	GO Category	GO:0005391	sodium:potassium-exchanging ATPase activity	Database	0
Category members	GO Category	GO:0005890	sodium:potassium-exchanging ATPase complex	Database	0
Category members	GO Category	GO:0005901	caveola	Database	0
Category members	GO Category	GO:0006754	ATP biosynthetic process	Database	0
Category members	GO Category	GO:0006812	cation transport	Database	0
Category members	GO Category	GO:0010107	potassium ion import	Database	0
Category members	GO Category	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Database	0
Category members	GO Category	GO:0015672	monovalent inorganic cation transport	Database	0
Category members	GO Category	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Database	0
Category members	GO Category	GO:0030315	T-tubule	Database	0
Category members	GO Category	GO:0030506	ankyrin binding	Database	0
Category members	GO Category	GO:0030955	potassium ion binding	Database	0
Category members	GO Category	GO:0031402	sodium ion binding	Database	0
Category members	GO Category	GO:0034220	ion transmembrane transport	Database	0
Category members	GO Category	GO:0043548	phosphatidylinositol 3-kinase binding	Database	0
Category members	GO Category	GO:0045822	negative regulation of heart contraction	Database	0
Category members	GO Category	GO:0046872	metal ion binding	Database	0
Category members	GO Category	GO:0060081	membrane hyperpolarization	Database	0
Category members	GO Category	GO:0071260	cellular response to mechanical stimulus	Database	0