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Query: ARL2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ARL2 0 -0.298 0.770 -1.100
ARL2 0 -0.298 0.770 -1.100 1.072 -1.021

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ARL2 Ubiquitylation K9 -0.349 _GLLTILKK(gl)_
ARL2 Ubiquitylation K71 -0.521 _LNIWDVGGQK(gl)SLR_

Background Information for ARL2:


Pubmed-ARL2 »
Uniprot-ARL2 »
Biogrid-ARL2 »
ProteomicsDB-ARL2 »

Tumorportal-ARL2 »
COSMIC-ARL2 »
GenomeRNAi-ARL2 »
Genecards-ARL2


Protein-protein Interactions for ARL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ALPI Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC104 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKFZp686O24166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NT5E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBB2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBB2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ARL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Small_GTPase IPR001806 0.65
Category members Gtr1_RagA IPR006762 0.63
Category members Small_GTPase_Rab_type IPR003579 0.51
Category members MIRO-like IPR013684 0.4
Category members Small_GTP-bd_dom IPR005225 0.32
Category members SRP_receptor_beta_su IPR019009 0.13
Category members Gprotein_alpha_su IPR001019 0.02
Category members Small_GTPase_SAR1 IPR006687 0
Category members Small_GTPase_ARF IPR024156 0


Protein complexes (CORUM database) featuring ARL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ARL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0070830 tight junction assembly Database 0.36
Category members GO Category GO:0005758 mitochondrial intermembrane space Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0019003 GDP binding Database 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0031113 regulation of microtubule polymerization Database 0.1
Category members GO Category GO:0019001 guanyl nucleotide binding Database 0.07
Category members GO Category GO:0051457 maintenance of protein location in nucleus Database 0.05
Category members GO Category GO:0005095 GTPase inhibitor activity Database 0.05
Category members GO Category GO:0051297 centrosome organization Database 0.04
Category members GO Category GO:0031683 G-protein beta/gamma-subunit complex binding Database 0.02
Category members GO Category GO:0007021 tubulin complex assembly Database 0.01
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0010811 positive regulation of cell-substrate adhesion Database 0
Category members GO Category GO:0031116 positive regulation of microtubule polymerization Database 0
Category members GO Category GO:0034260 negative regulation of GTPase activity Database 0


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