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Query: ARHGEF5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ARHGEF5 0 2.225 -1.480 2.200
ARHGEF5 0 2.225 1.110 -0.980

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ARHGEF5 Phosphorylation S662 -1.059 0.313 _DYSTVSAS(ph)PTALSTLK_
ARHGEF5 Phosphorylation S1125 -0.288 -0.574 _LESLSETPGPS(ph)SPR_
ARHGEF5 Phosphorylation S11 -0.663 -0.620 _GAS(ph)PPISAIEEFSIIPEAPM(ox)R_
ARHGEF5 Phosphorylation S1126 -0.717 _LESLSETPGPSS(ph)PR_
ARHGEF5 Phosphorylation S445 -1.196 _AEELS(ph)PAALSPSLEPIR_
ARHGEF5 Phosphorylation T1121 -0.492 _LESLSET(ph)PGPSSPR_

Background Information for ARHGEF5:


Pubmed-ARHGEF5 »
Uniprot-ARHGEF5 »
Biogrid-ARHGEF5 »
ProteomicsDB-ARHGEF5 »

Tumorportal-ARHGEF5 »
COSMIC-ARHGEF5 »
GenomeRNAi-ARHGEF5 »
Genecards-ARHGEF5


Protein-protein Interactions for ARHGEF5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARHGEF35 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ARHGEF5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PH_domain IPR001849 0.14
Category members SH3_2 IPR011511 0.08
Category members DH-domain IPR000219 0.05
Category members SH3_domain IPR001452 0


Protein complexes (CORUM database) featuring ARHGEF5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ARHGEF5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_240 BIOCARTA_PAR1_PATHWAY 0 1.11
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members Pathway Pathway_677 BIOCARTA_MYOSIN_PATHWAY 0 0.53
Category members Pathway Pathway_667 BIOCARTA_RHO_PATHWAY 0 0.3
Category members GO Category GO:0035023 regulation of Rho protein signal transduction Database 0.17
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0032319 regulation of Rho GTPase activity Database 0.14
Category members Pathway Pathway_1172 PID_RHOA_REG_PATHWAY 0 0.09
Category members GO Category GO:0005089 Rho guanyl-nucleotide exchange factor activity Database 0.08
Category members GO Category GO:0002408 myeloid dendritic cell chemotaxis Database 0
Category members GO Category GO:0032321 positive regulation of Rho GTPase activity Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0


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