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Query: ALYREF

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ALYREF 3 7.781 -0.280 0.640 0.073 0.076 0.370

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ALYREF Ubiquitylation K242 1.295 1.872 _NSK(gl)QQLSAEELDAQLDAYNAR_
ALYREF Phosphorylation S246 2.160 1.598 _QQLS(ph)AEELDAQLDAYNAR_
ALYREF Ubiquitylation K168 1.438 1.581 _KADALK(gl)AMK_

Background Information for ALYREF:


Pubmed-ALYREF »
Uniprot-ALYREF »
Biogrid-ALYREF »
ProteomicsDB-ALYREF »

Tumorportal-ALYREF »
COSMIC-ALYREF »
GenomeRNAi-ALYREF »
Genecards-ALYREF


Protein-protein Interactions for ALYREF
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCLAF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C17orf85 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC7 Cat. description Hein, Mann, Cell 2015


Protein Domains in ALYREF
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34


Protein complexes (CORUM database) featuring ALYREF
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 770 TREX complex Database 1.46
Category members Corum 5449 Splicing-associated factors complex Database 0.5
Category members Corum 785 Exon junction complex Database 0.29


Categories featuring ALYREF
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0006406 mRNA export from nucleus Database 4.09
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0046784 viral mRNA export from host cell nucleus Database 1.46
Category members GO Category GO:0032786 positive regulation of DNA-dependent transcription, elongation Database 1.27
Category members GO Category GO:0000346 transcription export complex Database 1.18
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0031124 mRNA 3'-end processing Database 0.91
Category members GO Category GO:0006369 termination of RNA polymerase II transcription Database 0.87
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0000018 regulation of DNA recombination Database 0.5
Category members GO Category GO:0035145 exon-exon junction complex Database 0.28
Category members GO Category GO:0031297 replication fork processing Database 0


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