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Query: ACTN4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACTN4 2 5.005 -0.050 0.190 0.936 1.929 -1.407 0.572 0.293

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACTN4 Ubiquitylation K125 1.906 _ALDFIASKGVK(gl)_
ACTN4 Ubiquitylation K760 0.273 1.507 _DAK(gl)GISQEQMQEFR_
ACTN4 Ubiquitylation K417 0.789 _LDHLAEK(gl)FR_
ACTN4 Ubiquitylation K592 -0.644 0.678 _EAILAIHK(gl)EAQR_
ACTN4 Ubiquitylation K350 0.585 _VQEK(gl)CQLEINFNTLQTK_

Background Information for ACTN4:


Pubmed-ACTN4 »
Uniprot-ACTN4 »
Biogrid-ACTN4 »
ProteomicsDB-ACTN4 »

Tumorportal-ACTN4 »
COSMIC-ACTN4 »
GenomeRNAi-ACTN4 »
Genecards-ACTN4


Protein-protein Interactions for ACTN4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYEF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait NCBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SIN3B Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TMOD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ACTN4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members CH-domain IPR001715 0.63
Category members CAMSAP_CH IPR022613 0.13
Category members EF_hand_dom IPR002048 0
Category members EF-hand_Ca_insen IPR014837 0


Protein complexes (CORUM database) featuring ACTN4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 725 P2X7 receptor signalling complex Database 0.53
Category members Corum 5655 Ternary complex (LRRC7, CAMK2a, ACTN4) Database 0


Categories featuring ACTN4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members Pathway Pathway_889 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0 0.9
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0008104 protein localization Database 0.5
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0051017 actin filament bundle assembly Database 0.47
Category members GO Category GO:0051272 positive regulation of cellular component movement Database 0.46
Category members GO Category GO:0031143 pseudopodium Database 0.46
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0070830 tight junction assembly Database 0.36
Category members GO Category GO:0030018 Z disc Database 0.32
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0030863 cortical cytoskeleton Database 0.24
Category members GO Category GO:0051271 negative regulation of cellular component movement Database 0.23
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0048549 positive regulation of pinocytosis Database 0.17
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0001725 stress fiber Database 0.04
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Disease phenotype Familial_idiopathic_steroid-resistant_nephrotic_syndrome_with_focal_segmental_hyalinosis Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001882 nucleoside binding Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0031093 platelet alpha granule lumen Database 0
Category members GO Category GO:0032417 positive regulation of sodium:hydrogen antiporter activity Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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