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Query: ACTN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACTN1 2 5.642 0.970 -0.750 1.417 -0.948
ACTN1 2 5.642 0.970 -0.750 0.790 0.055 0.246
ACTN1 2 5.642 0.970 -0.750 0.936 1.929 -1.407 0.572 0.293

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACTN1 Ubiquitylation K125 1.906 _ALDFIASKGVK(gl)_
ACTN1 Ubiquitylation K760 0.273 1.507 _DAK(gl)GISQEQMQEFR_
ACTN1 Phosphorylation Y12 1.047 _(ac)MDHYDSQQTNDY(ph)M(ox)QPEEDWDRDLLLDPAWEK_
ACTN1 Ubiquitylation K417 0.789 _LDHLAEK(gl)FR_
ACTN1 Phosphorylation S6 -0.679 0.700 _(ac)MDHYDS(ph)QQTNDYMQPEEDWDRDLLLDPAWEK_
ACTN1 Ubiquitylation K592 -0.644 0.678 _EAILAIHK(gl)EAQR_
ACTN1 Ubiquitylation K350 0.585 _VQEK(gl)CQLEINFNTLQTK_

Background Information for ACTN1:


Pubmed-ACTN1 »
Uniprot-ACTN1 »
Biogrid-ACTN1 »
ProteomicsDB-ACTN1 »

Tumorportal-ACTN1 »
COSMIC-ACTN1 »
GenomeRNAi-ACTN1 »
Genecards-ACTN1


Protein-protein Interactions for ACTN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ACTN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members CH-domain IPR001715 0.63
Category members CAMSAP_CH IPR022613 0.13
Category members EF_hand_dom IPR002048 0
Category members EF-hand_Ca_insen IPR014837 0


Protein complexes (CORUM database) featuring ACTN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5177 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) Database 0.31
Category members Corum 4025 Affixin-actinin(alpha) complex Database 0.22


Categories featuring ACTN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_1156 BIOCARTA_UCALPAIN_PATHWAY 0 1.12
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0017166 vinculin binding Database 1.01
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members Pathway Pathway_889 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0 0.9
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members GO Category GO:0051017 actin filament bundle assembly Database 0.47
Category members GO Category GO:0005916 fascia adherens Database 0.47
Category members GO Category GO:0031143 pseudopodium Database 0.46
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members Pathway Pathway_1093 PID_SYNDECAN_4_PATHWAY 0 0.28
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0051271 negative regulation of cellular component movement Database 0.23
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members Pathway Pathway_923 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS 0 0.18
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0048041 focal adhesion assembly Database 0.1
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_1178 BIOCARTA_CELL2CELL_PATHWAY 0 0.08
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_925 REACTOME_CELL_JUNCTION_ORGANIZATION 0 0
Category members Disease phenotype Autosomal_dominant_macrothrombocytopenia Autosomal dominant macrothrombocytopenia Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0031093 platelet alpha granule lumen Database 0
Category members GO Category GO:0042995 cell projection Database 0


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