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Query: ACLY

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACLY 1 3.880 1.120 -0.800
ACLY 1 3.880 1.120 -0.800 0.445 -0.254 -0.441 0.425 0.438

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACLY Ubiquitylation K1045 1.605 1.038 _VQILK(gl)DYVR_
ACLY Ubiquitylation K1134 0.533 0.628 _LK(gl)QGLYR_
ACLY Ubiquitylation K284 0.492 _VDATADYICK(gl)VK_
ACLY Ubiquitylation K58 0.165 0.356 _(ac)SAK(gl)AISEQTGK_
ACLY Ubiquitylation K542 -0.051 0.346 _SLQGK(gl)STTLFSR_
ACLY Phosphorylation S509 0.314 0.310 _TAS(ph)FSESR_
ACLY Ubiquitylation K1131 0.295 _SM(ox)GFIGHYLDQK(gl)R_
ACLY Ubiquitylation K151 0.204 _LGQEATVGK(gl)ATGFLK_
ACLY Phosphorylation T507 0.133 0.169 _T(ph)ASFSESRADEVAPAK_
ACLY Ubiquitylation K423 0.174 0.094 _DYQGPLK(gl)EHEVTIFVR_
ACLY Ubiquitylation K890 0.210 -0.008 _K(gl)PASFMTSICDER_
ACLY Ubiquitylation K689 -0.068 _GVTIIGPATVGGIKPGCFK(gl)_
ACLY Ubiquitylation K326 -0.599 -0.184 _LTLLNPK(gl)GR_
ACLY Ubiquitylation K220 -1.282 -0.263 _LNPEDIK(gl)K_
ACLY Ubiquitylation K834 -0.517 -0.548 _NQALK(gl)EAGVFVPR_
ACLY Ubiquitylation K319 0.218 -0.571 _SGASLK(gl)LTLLNPK_
ACLY Ubiquitylation K684 -0.182 -0.579 _GVTIIGPATVGGIK(gl)PGCFK_
ACLY Ubiquitylation K217 -0.283 -0.673 _AKPAM(ox)PQGK(gl)STTLFSR_
ACLY Phosphorylation S535 -0.762 -0.699 _KAKPAM(ox)PQDSVPS(ph)PR_
ACLY Ubiquitylation K972 -1.098 -0.797 _AGK(gl)DLVSSLTSGLLTIGDR_
ACLY Ubiquitylation K1032 -1.134 -0.933 _VK(gl)SINNPDMR_
ACLY Ubiquitylation K608 -1.107 _EILIPVFK(gl)NMADAMR_
ACLY Phosphorylation T501 -1.897 -2.164 _PIPNQPPTAAHTANFLLNASGSTST(ph)PAPSR_
ACLY Ubiquitylation K525 -1.747 -2.241 _AK(gl)PAMPQDSVPSPR_
ACLY Ubiquitylation K210 -0.990 _AK(gl)PAMPQGK_
ACLY Ubiquitylation K213 -0.329 _LLVGVDEK(gl)LNPEDIKK_
ACLY Ubiquitylation K523 -2.076 _K(gl)AKPAMPQDSVPSPR_
ACLY Ubiquitylation K552 1.114 _HTK(gl)AIVWGM(ox)QTR_

Background Information for ACLY:


Pubmed-ACLY »
Uniprot-ACLY »
Biogrid-ACLY »
ProteomicsDB-ACLY »

Tumorportal-ACLY »
COSMIC-ACLY »
GenomeRNAi-ACLY »
Genecards-ACLY


Protein-protein Interactions for ACLY
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NUP107 Cat. description Hein, Mann, Cell 2015


Protein Domains in ACLY
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring ACLY
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ACLY
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_3 KEGG_CITRATE_CYCLE_TCA_CYCLE 0 3.83
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members GO Category GO:0044262 cellular carbohydrate metabolic process Database 0.64
Category members GO Category GO:0004775 succinate-CoA ligase (ADP-forming) activity Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_6 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS 0 0.2
Category members GO Category GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Database 0.2
Category members GO Category GO:0006101 citrate metabolic process Database 0.13
Category members GO Category GO:0003878 ATP citrate synthase activity Database 0.13
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0035338 long-chain fatty-acyl-CoA biosynthetic process Database 0.1
Category members Pathway Pathway_2 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS 0 0.08
Category members GO Category GO:0048037 cofactor binding Database 0.08
Category members GO Category GO:0008610 lipid biosynthetic process Database 0.05
Category members GO Category GO:0031325 positive regulation of cellular metabolic process Database 0.04
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0009346 citrate lyase complex Database 0
Category members GO Category GO:0015936 coenzyme A metabolic process Database 0
Category members GO Category GO:0019432 triglyceride biosynthetic process Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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