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Query: ZCCHC8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ZCCHC8 0 -7.372 0.230 -0.260 -1.876 -3.179 -1.337 -1.994 -1.038

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ZCCHC8 Phosphorylation S598 0.975 1.077 _SEAGHASS(ph)PDSEVTSLCQK_
ZCCHC8 Phosphorylation S597 0.616 0.863 _SEAGHAS(ph)SPDSEVTSLCQK_
ZCCHC8 Phosphorylation S658 0.694 _IHS(ph)PIPDMSK_
ZCCHC8 Phosphorylation S649 0.158 -0.490 _LFPADTS(ph)PSTATK_
ZCCHC8 Phosphorylation T479 -0.884 -1.081 _GT(ph)PPPVFT(ph)PPLPK_
ZCCHC8 Phosphorylation T485 -2.305 _GT(ph)PPPVFT(ph)PPLPK_

Background Information for ZCCHC8:


Pubmed-ZCCHC8 »
Uniprot-ZCCHC8 »
Biogrid-ZCCHC8 »
ProteomicsDB-ZCCHC8 »

Tumorportal-ZCCHC8 »
COSMIC-ZCCHC8 »
GenomeRNAi-ZCCHC8 »
Genecards-ZCCHC8


Protein-protein Interactions for ZCCHC8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GBA Cat. description Hein, Mann, Cell 2015
Category members IP bait NCBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait RET Cat. description Hein, Mann, Cell 2015
Category members IP bait SNCA Cat. description Hein, Mann, Cell 2015
Category members IP bait TBCK Cat. description Hein, Mann, Cell 2015
Category members IP bait C1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HNRNPF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM4B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZC3H18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ZCCHC8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PSP IPR006568 0


Protein complexes (CORUM database) featuring ZCCHC8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1181 C complex spliceosome Database 2.39


Categories featuring ZCCHC8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Disease phenotype Autosomal_Recessive_Mental_Retardation Autosomal Recessive Mental Retardation Database 0


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