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Query: YARS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
YARS 1 5.666 -1.260 1.210 0.269 0.624 0.254

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
YARS Ubiquitylation K127 0.207 2.263 _GTDYQLSK(gl)EYTLDVYR_
YARS Ubiquitylation K513 0.184 0.210 _QTNFMTK(gl)LGSISCK_
YARS Ubiquitylation K10 0.602 0.107 _(ac)GDAPSPEEK(gl)LHLITR_
YARS Ubiquitylation K206 -0.015 _YLPALGYSK(gl)R_
YARS Ubiquitylation K32 1.046 _LKEILK(gl)ER_
YARS Ubiquitylation K335 -0.488 _K(gl)LASAAYPDPSK_
YARS Ubiquitylation K356 -0.587 _GPAK(gl)NSEPEEVIPSR_
YARS Ubiquitylation K380 0.526 _IITVEK(gl)HPDADSLYVEK_

Background Information for YARS:


Pubmed-YARS »
Uniprot-YARS »
Biogrid-YARS »
ProteomicsDB-YARS »

Tumorportal-YARS »
COSMIC-YARS »
GenomeRNAi-YARS »
Genecards-YARS


Protein-protein Interactions for YARS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MAP3K12 Cat. description Hein, Mann, Cell 2015
Category members IP bait MIB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R2A Cat. description Hein, Mann, Cell 2015
Category members IP bait PXDC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SIDT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in YARS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members aa-tRNA-synth_Ic IPR002305 0.01
Category members Tyr-tRNA-ligase IPR002307 0


Protein complexes (CORUM database) featuring YARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring YARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members GO Category GO:0000049 tRNA binding Database 0
Category members GO Category GO:0004831 tyrosine-tRNA ligase activity Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006437 tyrosyl-tRNA aminoacylation Database 0
Category members GO Category GO:0007165 signal transduction Database 0


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