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Query: WASF3

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
WASF3 0 1.089 -0.950 1.600 0.137 -0.055

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
WASF3 Phosphorylation S293 -1.620 _RSS(ph)VVSPSHPPPAPPLGSPPGPK_
WASF3 Ubiquitylation K169 0.110 _MLQDTK(gl)DIMK_
WASF3 Ubiquitylation K216 1.027 _MGQEFVESK(gl)EK_
WASF3 Ubiquitylation K218 0.488 _MGQEFVESK(gl)EK_

Background Information for WASF3:


Pubmed-WASF3 »
Uniprot-WASF3 »
Biogrid-WASF3 »
ProteomicsDB-WASF3 »

Tumorportal-WASF3 »
COSMIC-WASF3 »
GenomeRNAi-WASF3 »
Genecards-WASF3


Protein-protein Interactions for WASF3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ABI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC53 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TIMM50 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WASF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in WASF3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WH2_dom IPR003124 0.04


Protein complexes (CORUM database) featuring WASF3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring WASF3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members GO Category GO:0030032 lamellipodium assembly Database 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0014003 oligodendrocyte development Database 0.21
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members GO Category GO:0031643 positive regulation of myelination Database 0.08
Category members GO Category GO:0030041 actin filament polymerization Database 0.01
Category members Pathway Pathway_912 BIOCARTA_ACTINY_PATHWAY 0 0
Category members GO Category GO:0007010 cytoskeleton organization Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0


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