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Query: VRK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VRK1 0 1.023 -0.320 0.590 1.054 -0.770 0.352 0.310

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VRK1 Ubiquitylation K92 -0.698 _AAK(gl)PEQIQK_
VRK1 Ubiquitylation K301 0.185 -1.136 _NKPGEIAK(gl)YMETVK_
VRK1 Ubiquitylation K106 -0.001 _LK(gl)YLGVPK_

Background Information for VRK1:


Pubmed-VRK1 »
Uniprot-VRK1 »
Biogrid-VRK1 »
ProteomicsDB-VRK1 »

Tumorportal-VRK1 »
COSMIC-VRK1 »
GenomeRNAi-VRK1 »
Genecards-VRK1


Protein-protein Interactions for VRK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait VRK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C1orf212 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSD3B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC38A7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB42 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in VRK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0


Protein complexes (CORUM database) featuring VRK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring VRK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0007077 mitotic nuclear envelope disassembly Database 5.8
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0007084 mitotic nuclear envelope reassembly Database 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Disease phenotype Pontocerebellar_hypoplasia_type_1 Pontocerebellar hypoplasia type 1 Database 0
Category members GO Category GO:0005795 Golgi stack Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0


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