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Query: USP25

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
USP25 0 1.474 -0.970 0.900

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
USP25 Ubiquitylation K250 -0.329 0.581 _AVEILK(gl)DAFK_
USP25 Ubiquitylation K254 -0.426 0.176 _DAFK(gl)SNDSQQQDVSEFTHK_
USP25 Ubiquitylation K715 -0.174 -0.164 _ALQEK(gl)LLASQK_
USP25 Ubiquitylation K444 -0.638 -0.833 _YLSYGSGPK(gl)R_
USP25 Ubiquitylation K201 -1.591 -1.154 _LVLNYK(gl)PPSNAQDLPR_
USP25 Ubiquitylation K60 -1.743 _NAK(gl)TPQQEETTYYQTALPGNDR_
USP25 Ubiquitylation K520 -0.659 _SVIHK(gl)PFTQSR_
USP25 Ubiquitylation K584 -0.007 _TIELMYSDK(gl)SMIQVPYR_
USP25 Ubiquitylation K630 -0.071 _YNDIAVTK(gl)SSWEELVR_

Background Information for USP25:


Pubmed-USP25 »
Uniprot-USP25 »
Biogrid-USP25 »
ProteomicsDB-USP25 »

Tumorportal-USP25 »
COSMIC-USP25 »
GenomeRNAi-USP25 »
Genecards-USP25


Protein-protein Interactions for USP25
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CROT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GDI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRFN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAD23B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in USP25
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UCH/PAN2 IPR028889 0.62
Category members Peptidase_C19_UCH IPR001394 0.53
Category members Ubiquitin-int_motif IPR003903 0.49
Category members UBA-like IPR009060 0.17


Protein complexes (CORUM database) featuring USP25
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring USP25
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0004843 ubiquitin-specific protease activity Database 3.28
Category members GO Category GO:0004221 ubiquitin thiolesterase activity Database 1.36
Category members GO Category GO:0071108 protein K48-linked deubiquitination Database 0.88
Category members GO Category GO:0032183 SUMO binding Database 0.45
Category members GO Category GO:0070536 protein K63-linked deubiquitination Database 0.29
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members GO Category GO:0006464 cellular protein modification process Database 0
Category members GO Category GO:0006508 proteolysis Database 0


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